Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"RIG-I"”.
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LUBAC is required for the RIG-I mediated antiviral response
… (PAMPs), such as incoming viral genomes. The RIG-I like receptor family sense viral RNA in the host cell cytoplasm, with RIG-I sensing double stranded regions of RNA with an exposed 5’ triphosphate group, present in viruses such as Influenza and Zika. The resulting signalling platform …
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Structural Basis for the Activation of RIG-I/MAVS Antiviral Immune Signaling
The file named "XU-DISSERTATION-2015.pdf" is the primary dissertation file. The supplemental file named "Movie 1.mp4" may be viewed individually.
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Mechanism of Ubiquitin Induced Activation of RIG-I Like Receptors in Antiviral Innate Immunity
… pathogen associated molecular patterns, and trigger the expression of immune response genes. Two proteins of the RIG-I like receptor family, RIG-I and MDA5, are essential for the detection of viral RNA in the cytoplasm. Upon viral recognition, RIG-I and MDA5 activate the mitochondrial …
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Evasion of RIG-I/MDA5 and TLR3-mediated innate immunity by hepatitis A virus
… of extensive research. Cellular helicases RIG-I and MDA5, and Toll-like receptor 3 (TLR3) are PRRs that detect virus-specific double stranded RNA (dsRNA). Activation of these PRRs by dsRNA lead to their interaction with adaptor proteins, which engage downstream kinases to activate two …
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Characterization of The Roles of Carma3 and Bcl10 In Virus-Triggered Rig-I/Mavs Signaling Pathway
… virus infection, the innate immunity utilizes RIG-I family of receptors in the cytoplasm to initiate the production of type-I IFNs and proinflammatory cytokines by mitochondrial protein MAVS, which forms a prion-like structure to recruit TBK1and IKK complex to activate IRF3 and NF-κB, …
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The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
… vector-borne virus, depends on recognition by RIG-I and MDA5, cytosolic pattern recognition receptors (PRRs) of the RIG-I-like receptor (RLR) protein family that recognize viral RNA and activate defense programs that suppress infection. We evaluated the individual functions of RIG-I and MDA5 …
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The Role of HOIL 1 Ubiquitin Ligase Activity in MDA5 Antiviral Signaling
The RIG-I-like receptors (RLRs), RIG-I and MDA5, are innate sensors of RNA virus infections that are critical for mounting a robust immune response. RIG-I and MDA5 both signal to MAVS to induce antiviral cytokine induction but respond to different viruses and are activated by distinct mechanisms. …
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Decoding aberrant RNA Synthesis by the Influenza A Virus
… viruses. Within this intricate defence network, RIG-I is responsible for detecting viral RNAs in the host cell, initiating a signalling cascade that ultimately triggers the expression of interferons and innate immunity. Adding to this complexity, IFI16, another essential cellular factor, is …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
… 3 [TLR3] and retinoic acid inducible gene I [RIG-I]) contribute to CXCL10 induction in hepatocytes. CXCL10 mRNA and protein were measured in primary human hepatocytes (PHH) and hepatocyte lines harboring functional or non-functional TLR3 and RIG-I pathways following HCV infection or exposure …
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Cellular responses to external threats probed by super-resolution microscopy
… systems. Viral infection in mammalian cells triggers the immune response, a cascade of antiviral signaling proteins. For double stranded RNA (dsRNA) virus, the innate immune response starts from retinoic acid-inducible gene-I (RIG-I) protein which is a dsRNA sensor. For certain types of …
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Key Role of Lys63-Linked Polyubiquitination in Viral Activation of IRF3
… receptors family (PRRs). Among PRRs, RIG-I-like receptors (RLRs), including RIG-I, MDA5 and LGP2, are responsible for sensing intracellular viral RNAs. MAVS, a mitochondria-localized transmembrane protein, transduces signaling from RIG-I and MDA5 to activate downstream transcription …
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Innate sensing and regulation during enteric caliciviruses infections
… with the virus. Here, the presence of a RIG-I/STING-dependent innate response pathway that restricts the replication of noroviruses is described, and an attempt by the murine norovirus to subvert it through expression of an accessory protein is demonstrated. We show that both RIG-I and …
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Investigating the mechanisms behind the immunostimulatory activity of influenza A virus RNA polymerase mutations
… detected by the retinoic acid-inducible gene I (RIG-I), which recognises the partially double-stranded, 5′-triphosphorylated RNA structure that is formed by the protein-free 3′ and 5′ termini (viral promoter) of viral genomic segments as well as aberrant replication products. However, it remains …
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Sensing of Picornavirus Infections
… pattern recognition receptors is necessary to trigger an immune response through the expression of interferons (IFNs) and cytokines. For RNA viruses, which replicate in the cytoplasm, the cytoplasmic RIG-I like receptors are responsible for this sensing. The contributions of these receptors to …
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HIJACKING OF CELLULAR PATHWAYS BY NOVEL TICK-BORNE PHLEBOVIRUS
… been shown to correlate with the relocation of RIG-I signaling proteins into early endosomal-derived cytoplasmic structures positive for SFTS virus NSs. Moreover, ubiquitin, an important post-translational modifier required for initiation of the RIG-I signaling cascade, also localizes to SFTS …
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Viral and Cell Type Specific Host Factors that Contribute to Paramyxovirus Antiviral Responses
… mutants was dependent on production of dsRNA and RIG-I, an RNA sensing PRR. Overexpression experiments demonstrated that cytokine induction did not involve TLR3. However, IL-8 secretion was enhanced when mutant virus infected cells were challenged with a TLR3 agonist. We demonstrated that …
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Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
… associated molecular patterns (PAMPs). TLR3, RIG-I and MDA5, trigger complex intertwined signaling pathways in response to viral dsRNA leading to the activation of interferon regulatory transcription factors IRF3, IRF7 and NF-κB. These transcription factors mediate inflammatory process to …
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Single molecule investigation of antiviral signaling
Retinoic acid-inducible gene 1 (RIG-I) plays a major role in antiviral innate immunity by detecting cytoplasmic viral RNA and triggering the pathway that leads to transcriptional activation of type I interferon (IFN). Type I IFN induces a large set of genes called interferon-stimulated genes (ISGs) …
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Hepatitis C Virus NS3/4A Protease and the Intracellular Antiviral Response: Mapping Complex Virus-Host Interactions
Virus infection triggers an innate immune response characterized by host cell production of interferon (IFN). Intermediates of viral replication, including dsRNA, initiate a signaling cascade that is amplified within the cell and alerts neighboring cells of viral invaders. Recognition of dsRNA …
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