Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"RICTOR"”.
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Concomitant Targeting of The Mtor/Mapk Pathways: Novel Therapeutic Strategy In Subsets of Non-Small Cell Lung Cancer
… of clinical relevance. We identified <em>RICTOR</em> alterations (mutations, amplifications) in 17% of lung adenocarcinomas and found <em>RICTOR</em> expression correlates to worse overall survival. There was enrichment of MAPK pathway genetic aberrations in key oncogenes (e.g. <em>KRAS, …
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The Regulation of Mtorc2 Kinase Activity and Complex Integrity
… Under ER stress, the essential mTORC2 component, rictor,</p> <p>is phosphorylated by GSK-3β at Ser-1235. This phosphorylation event results in</p> <p>the inhibition of mTORC2 kinase activity by interrupting Akt binding to mTORC2.</p> <p>Blocking rictor Ser-1235 phosphorylation can attenuate the …
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Molecular signaling programs underlying neutrophil polarity and chemotaxis
… HL-60 cells, we describe a pivotal role for Rictor, a component of Mammalian Target of Rapamycin Complex 2 (mTORC2), in regulating assembly of the actin cytoskeleton during neutrophil chemotaxis. Depletion of Mammalian Target of Rapamycin (mTOR) and Rictor, but not Raptor, impairs actin …
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Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia
… (miR) HumanV2 arrays. The microarray identified Rictor, a key component to in the mTOR2 complex, as a novel downstream target of NOTCH1 signaling. Upon NOTCH1 inhibition, an increase in the expression of Rictor was observed, both at the transcript and protein levels. Initial computational …
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Identifying genes that are required for the maintenance of pancreatic ductal adenocarcinoma
… mTOR, and to a lesser extent, Raptor and Rictor, as genes that are important for the maintenance of PDAC both in vitro and in vivo. In addition, we show that inhibition of mTOR and Raptor are synthetic lethal in that PDAC lines are sensitive to their inhibition, while non-tumorigenic cell …
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Regulation of Exercise-Dependent Cardiac Growth by MicroRNAs
… of a network of genes including p85-alpha, Rictor, Lin7c and Fzd4. Collectively, the results of my thesis research identify miR-499 as a pivotal regulator of exercise-induced cardiac hypertrophy.
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… SPP1 promote nerve growth by upregulating mTORC2/Rictor pathway in neural cells. Conclusions: Our findings revealed that in vitro generated hTAMs can be exploited as a novel, multifaceted cell-based therapy for CNS injuries. TAMs integrate chemotactic, immune modulatory, metabolic and neurotrophic …
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Pten Signaling in Regulatory T Cells and Inflammatory Disease
… Consistent with this notion, deletion of Rictor, the obligate component for mTORC2, restores Treg cell function and stability in the absence of Pten. Similarly, partially restoring the activity of Foxo1, a downstream transcription factor negatively regulated by mTORC2 signaling, also …
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Novel Mechanisms of Kinase Independent Pro-Survival Functions of EGFR in Cancer
… by EGFR’s kinase-independent interaction with RICTOR and UT2 and activation of mTORC2/Akt signaling whereas inhibition of EGFR kinase function causes non-selective macro autophagy mediated by activation of mTORC1 signaling. To further support this, we have found an EGFR downregulating peptide …
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USING CHEMICAL AND PROTEOMICS APPROACHES TO STUDY THE FUNCTIONS OF SIRT6 AND KRAS
… forms a new mTOR complex without raptor or rictor in cells.
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Identifying and Targeting Adaptive Changes to Bet Inhibition In Ovarian Cancer
… that decreased Akt activation and increased Rictor activation after CN210 treatment served as a possible marker for the increased response seen with CN210 and INK-128 combination. Lastly, we demonstrated a significant reduction in tumor weight using CN210/INK-128 combination treatment in an …
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Comparative analysis of transcriptome of fracture healing under normal and hypophosphatemic conditions
… associated with these pathways included RICTOR and TEAD1.