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Showing 1 to 6 of 6 for “"RGS Proteins"”.
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Characterization of the Role of R7-RGS Proteins in Mammalian Retina and Vision
… of the Role of RGS7-family Proteins in Mammalian Retina and Vision</p><p>by</p><p>Matthew David Cain</p><p>Doctor of Philosophy in Biology and Biomedical Sciences</p><p>Molecular Cell Biology</p><p>Washington University in St. Louis, 2014</p><p>Professor Kendall …
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THE ROLE OF R7 REGULATORS OF G PROTEIN SIGNALING IN THE RETINA
<p>The R7 regulators of G protein signaling (R7 RGS), namely RGS6, RGS7, RGS9 and RGS11, are expressed in the retina along with its binding partner Gβ5. The RGS9-1 isoform is expressed only in retinal photoreceptors and rate-limits the recovery of rod phototransduction by acting as a member of the …
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Rgs16 is a Pancreatic Reporter of Chronic Hyperglycemia in Diabetes
… beta cells. Regulators of G-protein Signaling (RGS) proteins are feedback regulators of GPCRs. Their expression can be induced by GPCR or cross-talk signals to inhibit GPCR pathway, thereby indicating when and where GPCR signaling occurs. Our studies utilizing Rgs16::GFP transgenic mouse …
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Bioinformatics Discovery And Functional Characterization Of Lipid-Binding Lov Photoreceptors
… LOV photoreceptors are modular flavin-binding proteins that consist of discrete sensor and effector domains. Blue-light drives a LOV sensor to trigger a conformational change in photoreceptor structure that ultimately regulates the biochemical function of one or more of its fused effectors. The …
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Regulation der Genexpression und Promotoraktivität von RGS4 durch Leptin
… of known leptin target genes (Fibrinogen b, RGS4, SOCS3, PAP1, tPA, Ppap2a, SOD2, Tachykinin, LCN2) was investigated in Northern blots using different cytokines. None of these genes was activated by IFN-g, while stimulation of the IL-6 receptor subunit gp130 showed effects analogous to those …
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Untersuchungen zur Struktur und Wirkung von Pasteurella multocida Toxin
… 1205 und 1223 führte zur Inaktivierung des PMT-Proteins. Es wird vermutet dass, sowohl die identifizierten Histidine (His1205 und His1223) als auch Cystein-1165 an einer essentiellen Metallionenbindung beteiligt sind, die für die biologische Aktivität von PMT essentiell ist. Die Hemmung der …