Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"RGDS"”.
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Knowledge Translation in the Era of Precision Diagnostics: Examining the Use of Clinical Exome and Genome Sequencing for Rare Genetic Disease Diagnosis
… patients with suspected rare genetic diseases (RGDs) worldwide, and healthcare systems are challenged to optimize its use within their jurisdictions. This thesis aimed to examine the rapidly evolving scientific evidence base related to ES/GS and how it has been translated into diagnostic care …
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Genetic and Environmental Factors Related to Child and Parent Mental Health in the Context of Intellectual Disabilities
… group of CYP with rare neurogenetic disorders (RGDs) during the COVID-19 pandemic (CoIN). Within both cohorts, I investigated mental health in CYP with ID/RGDs and their parents/carers, as they both face elevated mental health risks and can be an important source of influence within the family. …
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In vivo responses of neural progenitor cells to extracellular matrix signaling under pathological conditions
… with another naturally occurring sequence, RGDS, de-rived from fibronectin. In this study, we were interested in the potential of the RGDS-peptide amphiphile as a possible cell scaffold for neural stem cell transplants. The in-troduction of a foreign material into the CNS can lead to a …
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Visible Light Cured Thiol-vinyl Hydrogels with Tunable Gelation and Degradation
… studies. In this thesis, pendant peptide RGDS was incorporated via two methods with high incorporation efficiency. The stiffness of hydrogels decreased when incorporating RGDS. The second objective of this thesis was to fabricate hydrogels using poly(ethylene glycol)-tetra-acrylate (PEG4A) …
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Design and Simulation of a Planar Crossed-Dipole Global Navigation Satellite System (GNSS) Antenna in the L1 Frequency Band
… of a thin block of Styrofoam¿¿ and Cumming’s RGDS-124 (microwave absorbing material) placed between the substrate and the ground plane (finite and infinite), simulated to increase the antenna performance. The prototype crossed-dipole antenna configurations were tuned and optimized based on the …
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Roles of coagulation factor XIII in the functions of blood platelets
… since it was abolished by treatment with RGDS. Moreover, platelet adhesion to FXIIIa was reduced partially, but significantly by either the specific integrin dnbPs antagonist tirofiban or the selective avp3-blocking antibody LM609, and abolished when used in combination. However, spreading …
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Biomimetic Surface Coatings from Modular Amphiphilic Proteins
… soluble block. For the case of diblocks with the RGDS integrin binding sequence, the capability for mediating cell attachment and spreading was demonstrated via control over ligand density on hydrophobic polymer surfaces. The case of diblock proteins with templating domains for inorganic materials …
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A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
… cells/µl) within hydrogels of PEG-conjugated RGDS adhesive peptide (3.5 mM) and PEG-conjugated protease sensitive peptide (6 mM). Robust hCB-EPC microvessels formed within the gel with invasion up to 150 µm depths and parameters of total tubule length (12 mm/mm2), branch points (127/mm2), and …
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The platelet laminin receptor : discovery of a 67kDA receptor for laminin on the membranes of human platelets : characterisation and isolation
… membrane receptors for many adhesive proteins, RGDS, at concentrations of up to 1mM, had no effect. The platelets of the two subjects with Glanzmann's Thrombasthenia adhered normally, definitively ruling out the involvement of GPIIb/IIIa, which is absent from these platelets. The isolation …