Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"RGD peptides"”.
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Ellipsoidal polyaspartamide polymersomes with enhanced cell-targeting ability
Nano-sized polymersomes functionalized with peptides are being increasingly studied for targeted delivery of diagnostic and therapeutic molecules. Earlier computational studies have suggested that ellipsoidal nanoparticles, compared to spherical ones, display enhanced binding efficiency with target …
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Role of extracellular environment in mechanical properties of human cardiac fibroblasts and myofibroblasts
… The addition of cell adhesion proteins, such as RGD peptides, resulted in a decrease in the shear modulus (G') of the hydrogel, as the peptides take up PEG arms which are potential crosslinks. This slight compromise to the structural integrity is relevant when tuning in vitro 3D extracellular …
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Effekt einer Antagonisierung der alpha- v-Integrine auf Angiogenese, Wachstum und Metastasierung solider Tumoren in vivo
… of alpha-v-integrins with a methylated cyclic RGD-peptide on angiogenesis, microcirculation, growth and metastasis formation of a solid tumor in vivo. Methods: Experiments were performed in the dorsal skinfold preparation of Syrian Golden hamsters bearing the amelanotic hamster melanoma …
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Use of growth factors and adhesive ligands to promote connective tissue progenitor colony formation from fresh marrow
… materials. In this work, we showed that synergy-RGD peptides, which incorporate the putative synergy site on fibronectin, can promote cell adhesion through both a5pl and av33 integrins. We then investigated the effects of tethered EGF on CTP colony formation in the context of defined adhesion …
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Photophysics of Organic Probes and their Applications in Bioimaging & Photodynamic Therapy
… surface of the nanoparticle was modified with RGD peptides for specific targeting. The nanoprobe exhibited good biocompatibility and highly selective RGD-mediated uptake in ?V?3 integrin-overexpressing cancers, while maintaining efficient fluorescence quantum yield and high photostability. In …
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Structually diverse Cu-64-labeled RGD peptide conjugates for PET imaging of αvβ3 expression
Radiolabeled receptor-binding peptides have emerged as an important class of radiopharmaceuticals for diagnostic imaging and cancer therapy. Following radionuclide labeling, the specific receptor-binding properties of the ligand can be exploited to guide the radioactivity to tissues expressing a …
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Materials and Nanostructured Coatings for Soft Tissue Regeneration
… attachment of Arginine-Glycine-Aspartic Acid (RGD) peptides, in order to promote cell adhesion and proliferation and obtain a “chemical biomimicry”. These peptide is the active sequence of laminin and fibronectin proteins, that are responsible for the adhesion of cells to the ECM. This chemical …
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Μεθοδολογίες μοριακής απεικόνισης με επισημασμένα νανοσωματίδια για τον ποσοτικό προσδιορισμό της χωροχρονικής κατανομής της αγγειογένεσης σε καρκινικούς όγκους
… απεικόνισης. Ένα νέο κυκλικό πεπτιδικό παράγωγο RGDfK (Arg-Gly-Asp-D‐Phe–Lys), το cRGDfK-Orn3-CGG, αξιολογήθηκε ως νέο μοριακό μέσο στόχευσης του καρκίνου μέσω της ειδικής στόχευσης των υποδοχέων ιντεγκρίνης ανβ3 που υπερεκφράζονται κατά την αγγειογένεση. Το νέο πεπτιδικό παράγωγο φέρει τον …
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INTEGRIN ALPHAVBETA3 AS THERAPEUTIC TARGET AND IMAGING BIOMARKER FOR VASCULAR ENDOTHELIAL CELLS AND CANCER EPITHELIAL CELLS
… that some endothelial integrins, such as the RGD sequence recognizing integrins αvβ3, αv5 and α5β1, are very important in the regulation of cell growth, survival and migration during angiogenesis and lymphangiogenesis. In particular, the αv integrins have key roles in embryonic development of …
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Exploring Chondrocyte Integrin Regulation of Growth Factor IGF-I Expression from a Transient pAAV Vector
Insulin-like Growth Factor I (IGF-I) is a growth factor that stimulates both mitogenic and anabolic responses in articular chondrocytes. While it has been shown that exogenous IGF-I can regulate chondrocyte integrins, little is known regarding regulatory effects of IGF-I produced from a transiently …