Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"RGD binding integrins"”.
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Conceptus-derived Fibrinogen and its Implication in Equine Pregnancy
… the conceptus secretes fibrinogen (an integrin-binding ECM). We hypothesized that conceptus-derived fibrinogen is converted into fibrin and aids in fixation via integrin receptors. We determined that RGD-binding integrins are expressed in endometrial and embryonic/fetal cells and interact with …
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Integrin-targeted cancer immunotherapy
Integrins are a family of heterodimeric cell surface receptors that are functionally important for cell adhesion, migration and proliferation. Certain integrins, especially those that are known to recognize the arginine-glycine-aspartate (RGD) motif, are heavily overexpressed in many cancers …
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Investigation of signalling pathways associated with the development of BRAF inhibitor resistance and treatment of melanoma
… that there is an increase in the expression of integrins during the development of BRAFi resistance. To understand which RGD binding integrins and mechanisms are involved in BRAFi resistance in melanoma cells, in this study, BRAFV600E mutant vemu-rafenib resistant cell lines were generated and …
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Functional Investigation of Dual αvβ3 and αllbβ3 Integrin Inhibition in Haematological and Solid Tumour Models
… Integrin adhesion receptors, particularly the RGD-binding integrin subfamily comprising αvβ3, αvβ5, αvβ6, αvβ8, αllbβ3, α5β1, α8β1 and αvβ1 are related to progress and spread of cancer and poor prognosis. Because of the importance of integrin biology in the regulation of cancer dissemination, …