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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 41 for “"RGCs"”.

  1. Growth Differentiation Factor 11 Promotes Survival of Mouse Retinal Ganglion Cells in Vitro through Smad2/3 Activation

    Yoo, Hyung-SukCarleton University2017

    … GDF11 protein can signal retinal ganglion cells (RGCs) to grow dendrites in vitro. The developmental expression pattern of GDF11 in RGCs and the impact of GDF11 on mammalian RGCs remain unknown. The current study investigated 1) the developmental time course of GDF11 expression in RGCs, 2) the …

    carleton Repository record

  2. The Maturation of Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells and Their Degeneration in Glaucoma

    VanderWall, Kirstin B.2020

    … to the degeneration of retinal ganglion cells (RGCs) and eventual blindness. A need exists to better understand the maturation of human RGCs as well as their degeneration, with the goal of developing new therapeutics diseases like glaucoma. Human pluripotent stem cells (hPSCs) provide an …

    iupui Repository record

  3. Cell-specific roles for CASK in the pathology of Optic Nerve Hypoplasia

    Kerr, Alicia MarieVirginia Tech2019

    … size, reduced numbers of retinal ganglion cells (RGCs), reduced RGC axonal diameter, and deficits in vision-related tasks. Further analysis on a homozygous partial loss of function variant (Caskfl/fl) also displayed ONH with reduced numbers of RGCs. In order to understand the mechanisms underlying …

    vt Repository record

  4. Understanding Chemotaxis in the Nematode Caenorhabditis elegans: From Molecules to Behavior

    Smith, Heidi2013

    … in particular, receptor-type guanylyl cyclases (rGCs). This thesis begins with my contribution to a study of the function of ASE asymmetry in chemotaxis. I, along with another graduate student, found that an additional four salt ions (Br-, Li+/, I /, Mg2+) are sensed by either ASER (right) or …

    columbia-diss Repository record

  5. The Albino Mouse Visual System: How Perturbed Retinal Development Leads to Altered Binocular Projections

    Bhansali, Punita2013

    … factor that is expressed in ventrotemporal RGCs from E14.5-E17.5, directs the ipsilateral projection. Zic2 regulates several programs of gene expression important for axon guidance and synaptic connectivity. Zic2 is expressed in fewer RGCs in the albino retina, coincident with the decrease …

    columbia-diss Repository record

  6. Neuronal Diversification Within the Retina: Generation of Crossed and Uncrossed Retinal Ganglion Cells

    Wang, Qing2013

    … ligands are expressed in retinal ganglion cells (RGCs) and at the chiasm, tightly regulating the development of the ipsilateral (uncrossed) and contralateral (crossed) retinal projections. Though many factors are known, their dysfunction leads to only partial misrouting of RGC axons. Moreover, the …

    columbia-diss Repository record

  7. Bioenergetic neuroprotection in experimental glaucoma

    Guymer, Chelsea Suzanne2020

    … degeneration of the retinal ganglion cells (RGCs). It is a leading cause of blindness worldwide. Although the pathogenesis of the most common variant, primary open-angle glaucoma, remains poorly understood, there is considerable evidence that energy insufficiency plays a pathogenic role. …

    adelaide Repository record

  8. Oxygen and Glucose Deprivation on Human Müller Cells (MIO-M1) and Human Organotypic Retinal Cultures (HORCs) in Relation to Glaucoma

    Aldarwesh, AmalUniversity of East Anglia2015

    … cells (MIO-M1), and retinal ganglion cells (RGCs) using the human organotypic retinal culture (HORC) model. Methods: MIO-M1 cells and HORCs were exposed to different levels of OGD using a custom-built chamber to control oxygen levels. Cell survival was evaluated using MTS and LDH assays while …

    east-anglia Repository record

  9. Human Organotypic Retinal Cultures as a model of human retinal ganglion cell degeneration in glaucoma. Effects of epigenetic regulation and mesenchymal stem cell derived growth factors.

    Hopes, MarinaUniversity of East Anglia2014

    … work was to investigate the long-term fate of RGCs in HORCs and to develop culture conditions to promote the RGC survival. The potential neurotrophic effect of mesenchymal stem cell derived growth factors on the RGC survival was studied and the role of epigenetic regulation of retinal cell gene …

    east-anglia Repository record

  10. Role of retinal inputs and astrocytes for the development of visual thalamus

    Somaiya, Rachana DevenVirginia Tech2022

    Axons of retinal ganglion cells (RGCs) send visual information to a number of retinorecipient regions in the brain. In rodents, visual thalamus receives dense innervations from RGC axons and is important for both image-forming and nonimage-forming visual functions. Retinal inputs invade visual …

    vt Repository record

  11. Expression and Requirement of Epithelial Fatty Acid- Binding Protein in Neuronal Axon Growth

    Allen, Gregory William

    … EFABP localized to retinal ganglion cells (RGCs) from E14 through P10, being confined to RGC somas on E14 but localized to axons by E15. Western immunoblotting revealed that on E18, P1, and P10, E-FABP levels were 3-4 times greater than adult levels, but decreased by 50% on P15. Furthermore, …

    loma-linda Repository record

  12. Hydrogen Sulfide in Glaucoma: Delivery System, Hypotensive and Neuroprotective Effects

    Mhatre, SusmitCreighton University2023

    … degeneration of retinal ganglion cells (RGCs). More than 80 million people, including 3 million Americans, have glaucoma. Increased intraocular pressure (IOP) is a distinct marker of glaucoma. IOP in glaucoma increases from the healthy range of 10-21 mmHg to the glaucomatous level of …

    creighton Repository record

  13. The mechanical regulation of Eph/ephrin signalling in the developing Xenopus brain

    Sipkova, JanaUniversity of Cambridge2022

    … on glass and tissue-culture plastics, ventral RGCs responded to ephrinB on glass, while dorsal RGCs did not. However, on soft substrates mechanically mimicking brain tissue, both dorsal and ventral RGCs responded to ephrinB to the same degree. This suggested that on substrates of stiffness …

    cambridge Repository record

  14. Understanding angiosperm genome interactions and evolution: insights from sacred lotus (Nelumbo nucifera) and the carrot family (Apiaceae)

    Peery, Rhiannon MUniversity of Illinois at Urbana-Champaign2015

    … in addition to other rare genomic changes (RGCs). To investigate the distribution and mechanism of IGT in species of the apioid superclade and the variable boundary between the two single copy regions and the IR, the complete plastomes of Anethum graveolens, Foeniculum vulgare, Carum carvi, …

    uiuc Repository record

  15. Investigating the role of ZEB2 in the establishment of neuroepithelial architecture and axon tract formation

    Giandomenico, Stefano LucaUniversity of Cambridge2020

    … cells (NECs) before the switch to radial glia (RGCs). By establishing a human embryonic stem cell (hESC) model of ZEB2 heterozygous loss-of-function we show that this gene modulates the changes in cell-cell contacts at the transition from NECs to RGCs. Upon partial loss of ZEB2, changes in cell …

    cambridge Repository record

  16. Estimating light edge velocity based on retinal ganglion cell spike trains

    Eisenman, AdamMassachusetts Institute of Technology2007

    … measured from the retinal ganglion cells (RGCs). We present various algorithms for doing so and present sensitivity analysis of such algorithms. We test the performance of the algorithms on data recorded from retina and on data produced by simulation. We find that we are able to extract …

    mit Repository record

  17. Advanced technologies for spatio-temporal control of neural circuits using optogenetics

    Pisano, FilippoUniversity of Strathclyde2016

    … in genetically-targeted retinal ganglion cells (RGCs) with a large scale approach. This method is a versatile approach that can be applied to characterise the many molecular types of RGCs. The integration of two-photon imaging and MEA recordings proved to be more arduous, yet applicable. Retinal …

    strathclyde Repository record

  18. Towards Mammalian Retinal Regeneration: Cell Signaling in Re-Differentiating Mouse Müller Glia and Transcriptional Regulation of the Axonal Guidance Receptor EPHA5

    Beach, Krista MarieUniversity of Houston2016

    … (RGC) synaptic termination zones. Therefore, new RGCs will need to express EphA5 and EphA6 at levels appropriate for their retinal location. Specific Aim 2 addressed the regulatory hierarchy controlling EphA5 and EphA6 expression in the mouse retina. POU4F2 is a RGC-specific transcription factor …

    houston Repository record

  19. Multipronged Approach to Study Glaucoma-Associated Phenotypes

    Chintalapudi, Sumana Rameshbabu2017

    … a group of conditions characterized by death of RGCs, increase in intraocular pressure is usually a precursor to glaucoma and irreversible optic neuropathy leads to visual impairment and blindness. Recent advances have seen a surge of new ideas and technologies to aid in the early detection, …

    tenn-hsc Repository record

  20. Influence of retinal states on the development and maintenance of retinofugal projections

    Morhardt, Duncan2020

    … activity only similar P14 nobxGβ5-/- and Gβ5-/- RGCs. This suggests that the critical period of eye-specific segregation closes shortly after P14 and that R7RGS activity is critically important to postnatal RGCs. Next, I investigated the aged visual system via the retinofugal projections of mice …

    vcu Repository record

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