Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"RET"”.
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RET Mediated Gene Expression and Cell-Migration
The RET receptor tyrosine kinase is important during development of neural crest-derived tissues, particularly the enteric and sympathetic nervous systems, and in kidney morphogenesis. Activation of RET requires complex formation between a member of the Glial cell line-Derived Neurotrophic Factor …
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Systematic Identification of Interaction Partners of RET Receptor Isoforms
The REarranged during Transfection (RET) receptor tyrosine kinase is pivotal for normal development of human tissues, but is also an oncogene driver involved in several human cancers. Alternative splicing at the 3’ end of the RET gene produces two conserved protein isoforms, RET9 and RET51, that …
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RET receptor activation targets expression of the pleiotropic cytokine interleukin-11
The RET receptor has diverse roles in development and disease, modulating proliferation, survival, and migration of cells. Ligand-independent constitutively active forms of RET can lead to thyroid neoplasia. Missense mutations are causative agents in multiple endocrine neoplasia type 2 (MEN 2), …
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A discrete RET Model for Micro- and Millimetre Wave Propagation through Vegetation
… based on the Radiative Energy Transfer theory (RET) which was discretised to accommodate forests formed by different vegetation species with their distinct propagation characteristics. The discretised model computational structure, comprises several element cells, whose characteristic …
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The Fate and Behavior of Ret-expressing Tip Cells in Kidney Development
… interactions in which a tubular epithelium, the ureteric bud, undergoes successive rounds of branching within the metanephric mesenchyme. Signaling through the receptor tyrosine kinase RET is required for the normal progression of this developmental program. A complete portrait of the …
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Einfluss des GDNF-Rezeptors Ret auf die Erholung des nigrostriatalen Systems im MPTP-Mausmodell der Parkinsonerkrankung
… ohne Erfolg geblieben. Die Aktivierung des Ret- (Rearranged during transfection) Rezeptors durch den Glial cell line-derived neurotrophic factor (GDNF) wurde als wichtiger Differenzierungs- und Überlebensfaktor für dopaminerge Neurone des Mittelhirns in vorklinischen Experimenten …
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Mechanistic Study of Fragile Site Breakage by Investigating RET/PTC Rearrangements, a Common Cause of Papillary Thyroid Carcinoma
Chromosomal fragile sites are non-random regions of the genome with a predisposition to the formation of DNA breaks. Common fragile sites, which are found in all individuals, often coincide with regions mutated in cancer, and therefore are believed to play a role in carcinogenesis. However, there …
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DNA FRAGILE SITE BREAKAGE AS A MEASURE OF CHEMICAL EXPOSURE AND PREDICTOR OF THE SUSCEPTIBILITY TO FORM CHROMOSOMAL REARRANGEMENTS
… of chromosomal rearrangements, we focused on RET/PTC rearrangements in papillary thyroid carcinoma. All genes participating in the two most common types of RET/PTC rearrangements, RET/PTC1 and RET/PTC3, are located within common fragile sites. Fragile sites are sensitive to a variety of …
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Effect of the Pdgfbʳᵉᵗ mutation on cardiovascular homeostasis
… of mesenchymal stem/stromal cells (MSCs). Pdgfbret/ret mutantmice are pericyte-deficient. The PDGFB retention motif is deleted, reducing PDGFB retention in the pericellular space and extracellular matrix and therefore pericyte recruitment during angiogenesis. This reduction in vascular pericyte …
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The winds of change: the political ecology of renewable energy transition in Vermont
… a case study of renewable energy transition (RET) in Vermont, illustrated by a recently completed commercial wind project in the Lowell Mountains. Preliminary analysis maps out the current political landscape of Vermont's RET - its stakeholders, political climate, and important policy …
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Expression and function of GDNF family ligands and their receptors by human immune cells
… besteht: Die Signal-transduzierende Komponente RET wird sowohl von GDNF als auch von NTN benutzt. RET wird von 21 Exonen kodiert und kommt in multiplen Spleiß-Varianten vor. Für die Liganden-Spezifität ist eine zweite Rezeptorkomponente verantwortlich, ein Mitglied der GFR-Familie. GFRa-1 bindet …
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Investigating complex I dynamics and ROS production in ischaemia-reperfusion injury
… can produce ROS via reverse electron transfer (RET), which is driven by a large protonmotive force (∆p) in conjunction with a reduced coenzyme Q (CoQ) pool, with the required electrons deriving from succinate oxidation. ROS causes severe damage to cellular components, leading to cell death and …
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Enhancing the relationship between the landscape of energy transition and the ecosystem services
… development of Renewable Energy Technologies, RET, to improve the transition of the production of energy from fossil fuels sources to renewable energy sources, RES. More than decades before, the energy transition towards renewable energies emerges as a relevant objective of the European …
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Mutationen der Succinyldehydrogenase Untereinheit D bei Patienten mit Phäochromozytom
… vorkommen. Mit dem SDHD-Gen wurde neben VHL, RET und NF1 ein weiteres Kandidatengen für familiäre Phäochromozytome gefunden. Ziel der Arbeit war es, ein nicht ausgewähltes Kollektiv von Patienten mit sporadischen Phäochromoyztomen auf Mutationen im SDHD-Gen zu testen und die Vererbung und …
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Developing an adjunct therapy to mechanical thrombectomy in a murine model of stroke ischaemia reperfusion injury
… (SDH). This drives reverse electron transport (RET) via complex I of the mitochondria to generate harmful reactive oxygen species (ROS) in a process known as RET-ROS. The SDH inhibitor disodium malonate (DSM) has been reported to enter cells via monocarboxylate transporter 1 (MCT1) to inhibit …
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Extraction of Input Parameters for the Theory of Radiative Energy Transfer Using Deconvolution.
… the theory of Radiative Energy Transfer (RET) is one of these models and provides an accurate analysis of radiowave propagation through a vegetation media. <br/> <br/>Extensive measurements have been designed and conducted in a controlled indoor environment to provide valuable measurement …
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The Effect of Protein Blend Supplementation and Resistance Exercise on Skeletal Muscle Growth and Adaptation
… growth during resistance exercise-training (RET) as compared to a commonly used single protein source. I tested this hypothesis in the acute and chronic response to exercise and protein ingestion via two separate randomized double-blinded clinical trials. In the first clinical trial 20 young …
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Applied molecular quantum electrodynamics: geometric aspects of the efficiency of photonic interactions
… to the analysis of resonance energy transfer (RET), molecular absorption and emission, and light scattering by molecules. An MQED framework describes such processes as a series of microscopic photonic interaction events. Multi-interaction processes entail intermediate states of the system’s …
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Elucidating the mechanism of mitochondrial superoxide production in pro-inflammatory macrophages
… superoxide by reverse electron transport (RET) at complex I. However, this has not been demonstrated and the mechanism of mitochondrial superoxide production is unknown. Furthermore, the influence of LPS induced metabolic reprogramming on mitochondrial ROS (mtROS) production has not been …
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The Impact of Family History On Medullary Thyroid Cancer In Men2A Patients
… reviewed for codon mutated and proportion of <em>RET </em>mutation carriers with MTC. Individuals with MTC were classified as having local or distant MTC and whether they had progressive MTC. MTC status and age were assessed at diagnosis and most advanced MTC stage. For those without MTC, age was …
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