Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"REM sleep behaviour disorder"”.
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An Investigation of the Clinical Predictors of Impulse Control Disorders in Patients with Parkinson's Disease
… disease (PD) experience impulse control disorders (ICD), which can result in serious negative consequences. Although clarifying the risk factors of ICD can inform tailored intervention strategies, the clinical predictors of ICD are poorly understood. The present study provides a …
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Inhibitory Control of Muscle Activity in Sleep
… thesis, I examined the inhibitory control of REM sleep motor activity using both a pharmacological rat model and a genetic mouse model. I characterized the role for GABA and glycine in mediating the REM-specific suppression of muscle activity as well as their involvement in regulating the …
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PLASMA JNK3 AS A NOVEL PERIPHERAL BIOMARKER IN ALZHEIMER'S AND PARKINSON'S DISEASES: EARLY DIAGNOSIS AND DISEASE MONITORING
… Parkinson’s diseases (PD) are neurodegenerative disorders that share overlapping molecular mechanisms but still lack accessible, disease-specific peripheral biomarkers for early diagnosis and disease monitoring. This thesis investigated the potential of c-Jun N-terminal kinase 3 (JNK3), a …
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A study of ultra-high field strength structural and spectroscopic MR imaging in dementia with Lewy bodies and Alzheimer’s disease
… cognitive fluctuations, rapid eye movement (REM) sleep behaviour disorder (RBD), and parkinsonism. In this PhD thesis I present a detailed investigation of neuroimaging changes found in DLB compared to in AD, in comparison to cognitively healthy older adults, using ultra-high field, 7 tesla …
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Investigating immunosuppression as a disease modifying strategy in Parkinson's disease
… well as the profile of a group of patients with REM sleep behaviour disorder (RBD). This analysis illustrates the potential utility of FBC-derived variables as biomarkers in PD, and positions innate immune cell populations, particularly classical monocytes and natural killer (NK) cells, as …