Global ETD Search
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Showing 1 to 5 of 5 for “"RDH10"”.
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RDH10 is Necessary for Initial Vagal Neural Crest Cell Contribution to Embryonic Gastrointestinal Tract Development
Retinol dehydrogenase 10 (RDH10) catalyzes the first oxidative step in the metabolism of vitamin A to its active form retinoic acid (RA). Insufficient or excess RA can result in various congenital abnormalities, such as Hirschsprung disease (HSCR). In HSCR, neurons are absent from variable lengths …
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Skeletal element elongation and interdigital tissue regression in developing bat limbs: a gene expression analysis
… with genes involved in RA synthesis ( Rdh10 , Aldha2 ) , degradation ( Cyp26b1 ) and signalling (Rar β) expressed in bat limbs. Altered expression patterns of Aldha2 and Cyp26b1, indicate that this pathway may be modulated in the forelimb. Meis2 is suggested to play a role in …
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The role of retinoic acid in glioma growth control
… retinal, ADH1A, ADH1B, ADH1C, ADH4, ADH7, RDH5 RDH10, RDH11 and RDH16 were all significantly lower in high grade glioma. The expression levels of the genes involved in the oxidation of retinal to retinoic acid, ALDH8A1, and ALDH1A1 (RALDH1) are also significantly reduced in high grade glioma. …
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Regulation of morphogen signalling during neural patterning in the Xenopus embryo
… we present Xenopus retinol dehydrogenase-10 (XRDH10) as a critical enzyme for embryonic vitamin A metabolism and retinoic acid (RA) synthesis in the developing embryo. We show that XRDH10, which oxidizes vitamin A to retinal, is transcriptionally inhibited by RA, suggesting negative feedback …
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Establishment of retinoic acid gradients in the early development of Xenopus laevis
… Xenopus Homolog der Retinol-Dehydrogenase 10 (XRDH10) vermittelt den ersten Schritt der RA Synthese, die Oxidation von Retinol zu Retinal. XRDH10 ist spezifisch in der dorsalen Blastoporuslippe exprimiert und in anderen Domänen, in welchen teilweise eine Überlappung mit XRALDH2 Expression zu …