Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"RDEB"”.
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Identification of OATP1B3 as a potential therapeutic target in Recessive Dystrophic Epidermolysis Bullosa Associated Squamous Cell Carcinoma
… Recessive Dystrophic Epidermolysis Bullosa (RDEB) is one of the most debilitating variants of the disease and patients are predisposed to developing aggressive cutaneous Squamous Cell Carcinoma (SCC). Unlike SCC in the general population, the primary cause of RDEB associated SCC is not …
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The Role of Dermal Architecture in Wound Healing and Tumour Differentiation
… of recessive dystrophic epidermolysis bullosa (RDEB) where trauma-induced blisters cause morbidity leading to skin cancer (SCC). Previous work done in the laboratory has identified that the dermal matrix composition drives tumour development in patients with RDEB (Ng, Pourreyron et al. 2012), …
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Targeting mutant p53 in cSCCs
… recessive dystrophic epidermolysis bullosa (RDEB) and Xeroderma Pigmentosum (XP) patients. cSCC patients that display regional metastasis have a 5-year survival rate of 25-50%, whilst this rate is close to 0% in RDEB patients with multiple cSCCs.<br/><br/>Wild-type p53 (wt-p53) has been shown …