Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"RCC1"”.
-
Molecular Mechanisms of Mitotic Spindle Assembly and Accurate Chromosome Segregation
… triggers a metaphase delay and disrupts the RCC1-dependent Ran-GTP gradient. Addition of mirin to mammalian cells reduces RCC1 association with mitotic chromosomes and changes the confirmation of RCC1. Thus, the MRN-CtIP pathway contributes to Ran-dependent mitotic spindle assembly by …
-
The Effect of Mebendazole and RAN Mediated Pathways on Human Breast Cancer Cells
… further analysed the knockdown effect of RAN, RCC1, SKIL, and METTL7A invasion and metastasis of breast cancer cells. Mebendazole also reduced the IC50 of Paclitaxel and downregulated Ran expression in MCF10A, MDA MB231, and MCF7 breast cell lines. Finally, in vivo, a chorioallantoic membrane …
-
Algorithmic Developments for Sequence Analysis, Structure Modeling and Functional Prediction of Proteins
… with regulator of chromosome condensation (RCC1). This prediction has been validated by experimental data. Second, a hierarchical structure classification of thioredoxin-like fold proteins has been carried out, which promotes understanding of fold definitions and sequence-structure-function …
-
Subcellular localisation and functional analysis of UVR8, a UV-B specific signalling component in Arabidopsis
… the human regulator of chromatin condensation (RCC1) but differs both in activity and function. The phenotype of uvr8 mutant plants is characterised by an increased susceptibility to UV-B and the lack of the UV-B-specific induction of genes involved in UV-protection, such as CHS (encoding the …
-
UV-resistance locus 8 and UV-B specific signaling in Arabidopsis thaliana
… in humans REGULATOR OF CHROMATIN CONDENSATION 1 (RCC1). The wide variety of plant species that did show UVR8-like proteins suggests that this particular means of UV-B acclimation may have arisen relatively early with the colonisation of land plants. Interestingly, many of these likely homologues …