Global ETD Search
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Showing 1 to 3 of 3 for “"RCAN1"”.
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Modulatoren des Calcineurin-NFATc-Signalweges in humanen TH-Zellen
… für die Calcineurinaktivität ist RCAN1, das vermutlich den Calcineurin-NFATc-Signalweg über einen negativen Rückkopplungsmechanismus reguliert. Hier wurde gezeigt, daß RCAN1 in humanen TH-Zellen exprimiert wird. Die Spleißvariante RCAN1-1 ist in ruhenden T-Zellen basal exprimiert …
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FHL2 Inhibits Calcineurin and Represses Pathological Cardiac Hypertrophy
… expression of the NFAT target genes RCAN1.4 and BNP in FHL2-/- hearts as compared to WT. To determine whether the effect of FHL2 on the abundance of NFAT target gene transcripts was mediated by calcineurin-NFAT-dependent transcription, HEK 293 cells were transfected with luciferase …
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Molecular Basis and Modification of a Neural Crest Deficit in a Down Syndrome Mouse Model
… the involvement of the Hsa 21 genes DYRK1A and RCAN1 in regulation of signaling pathways including NFATc (NFAT2), a transcription factor known to influence cellular proliferation and, later, bone development, we hypothesized that dysregulation of these genes could underlie the cellular deficit …