Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry"”.
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Analysis of nerve terminal dysfunction in autoimmune neuropathy
In studies on the pathophysiology of the autoimmune neuropathy, Miller Fisher syndrome (MFS), monoclonal antibodies to the disialosyl epitopes on GQ1b, GT1a and GD3 gangliosides have been produced. Antibodies to these complex gangliosides are thought to be crucial in the pathogenesis of MFS. These …
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Response of sensorimotor pathways of the spinal cord to injury and experimental treatments
Many spinal cord injuries (SCI) are incomplete, variable numbers of spared fibres passing the lesion level and supporting some residual function below the injury. One approach to improving function following injury is to develop therapies that maximise the potential of these spared fibres. The aim …
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The entrainment of brain oscillations through transcranial alternating current stimulation (tACS) delivered at off-peak frequencies.
It has been demonstrated that endogenous brain oscillations can become entrained to rhythmic stimulation. Four studies were conducted to investigate the possibility of modulating endogenous frequency peaks, through entrainment, from stimulation delivered at off-peak frequencies. Study 1 utilised …
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The effect of mindfulness movement therapy on arm and hand function in people with and without stroke
Upper extremity motor deficit is a big issue in patients with stroke. Mindfulness meditation may have potential to improve arm and hand function in stroke patients. However, there is no mindfulness programme specifically concerned with motor performance. Therefore, this thesis proposed a new …
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Characterisation of a recombinant human cysteine dioxygenase
Cysteine Dioxygenase is an enzyme that catalyses the reaction of cysteine to cysteinesulfinic acid and is thought to regulate the intracellular concentrations of its substrate. The enzyme may also be involved in the oxidation of exposed sulfidrils of protein and by implication, involved in cell …
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Electrophysiological characterization of a mouse deficient for oligophrenin1: a mouse model of X-linked mental retardation
Mental retardation is the most common brain disease. One of the first genes identified in X-linked mental retardation (XLMR) was the OPHN-1 gene. Mutation of this gene has been described in patients with moderate to severe cognitive impairments. MR is characterized by reduced cognitive function …
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From objects to action: a neuropsychological analysis
This thesis is concerned with the factors that determine the performance of everyday action. Six empirical chapters are subsequently presented. First, I sought to investigate the effects of the presence of distractors and of task load on the performance of everyday life tasks, comparing a patient …
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NEUROPHYSIOLOGICAL CORRELATES OF ECSTASY/MDMA USE ON EXECUTIVE FUNCTIONING
The purpose of this thesis was to assess the integrity of the serotonin system, by measuring the neurophysiological response to tasks that measure executive functions, and neuroendocrine function in ecstasy users and non-users. Each of the proposed executive functions outlined in Miyake et al.’s …
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DOMAIN-SPECIFIC AND DOMAIN-GENERAL INFLUENCES ON EARLY MATHEMATICAL SKILLS: A LONGITUDINAL STUDY
Two domain-specific quantity systems have been proposed; the “Precise Number System” for small precise numerical representations, and the “Approximate Number System” for imprecise numerical representations (Feigenson, Dehaene, & Spelke, 2004). The efficiency of these systems has been individually …
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The role of the rostral prefrontal cortex in the context of the aesthetic experience
The evaluation of visual art involves sensory, emotional and cognitive processes that lead to an aesthetic judgement or an aesthetic emotion (e.g. beauty). Aesthetic experiences are multisensory processes that undergo a variety of stages. Early processes occur in the visual and sensory cortices, …
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Neural Correlates of Tactile Attention: Behavioural measures and event-related brain potentials of inhibition of return, exogenous and endogenous attention in touch
The studies presented in this thesis investigated the neural correlates of attention in touch. In particular, the electrophysiology of exogenous tactile processing and inhibition of return (IOR) - an area previously unexplored. In all studies a variation of the Posner cue-target paradigm was used. …
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Neurophysiological correlates of preparation for action measured by electroencephalography
… way for studying preparation for action in neuroscience is to divide it in temporal preparation (when to respond) and event preparation (what response to make). In Chapter 2, we identified electrophysiological signs of implicit temporal preparation in a task where such preparation was not …
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The role of mindfulness in physical activity
Despite public health campaigns to promote physical activity (PA), physical inactivity affects 60% of the world population and continues to pose a risk of overweight and obesity, type 2 diabetes, and related cancers. Current interventions show small to moderate changes in PA and limited long-term …
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The effect of pain on human time perception
This thesis explored the effect of pain on human temporal perception. This aim was achieved firstly by systematically testing the way in which pain experience affects duration estimates, and memory for duration and secondly by examining whether it was possible to reduce perceived duration of pain …
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Spinal interneurons in sensorimotor integration
Even though spinal cord research has expanded enormously during the past decades, we still lack a precise understanding of how spinal interneuron networks perfectly integrate sensory feedback with motor control, and how these neuron circuits give rise to specific functions. The present study thus …
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Investigating molecular mechanisms of neuronal regeneration: a microarray approach.
Injury to the peripheral nervous system (PNS) stimulates a finely regulated regenerative response that generally leads to some recovery of function. In contrast, the response to injury in the adult mammalian central nervous system (CNS) is abortive and adult CNS neurons do not normally regenerate. …
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Transcranial alternating current stimulation to areas associated with the human mirror neuron system reveals modulation to mu-suppression and corresponding behaviour
This study was carried out in order to validate the use of EEG mu (μ) suppression as an index of human mirror neuron system (hMNS) related activity. The hMNS is characterized by neuronal activity that responds to both action observation and execution of the same movement. This activity has been …
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Neural Substrates of Human Perceptual Decision-Making
Perceptual decision-making describes the process of choosing one of at least two response alternatives based on sensory evidence. This sensorimotor process underlies a range of human behaviours and has been studied extensively by both psychologists and neuroscientists. There is now a consensus, …
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