Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"RC0254 Neoplasms. Tumors. Oncology (including Cancer)"”.
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Thinking self after bowel cancer: an embodied interpretation and art-iculation
… to an understanding of the experience of cancer survivorship by focusing on survivors’ “comprehending” of self vis-à-vis cancer, specifically by exploring embodied dimensions of their comprehending. This approach sits within an interpretive phenomenological paradigm. It draws, in …
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Endocrine therapy mediated hot flushes in breast cancer: can exercise help?
… a side effect of endocrine therapy for breast cancer treatment; and are possibly more frequent and severe than post-menopausal hot flushes. Many breast cancer patients do not adhere to the endocrine therapy guidelines due to the frequency and severity of hot flushes, which significantly …
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Identification of exosomal proteins in primary human bronchial tracheal epithelial cell HBTE and the H358, THP1 and MCF7 cell lines
Background: Early detection of cancer is of paramount importance for successful treatment. Unfortunately, this is currently complex and time consuming. New sources of biomarkers are needed to improve. Exosomes are nano sized extracellular vesicles released by almost all cells have gained much …
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Molecular changes involved in oral cancer progression and their relevance to keratinocyte immortalisation
Oral cancer has caused great concern in all of the western countries over the past two decades because of its progressively increasing incidence, mainly in young males, and its consistently low 5-year survival rate. Oral premalignant lesions (dysplasias) are thought to precede the development of …
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Gene expression analysis of head and neck cancer development
Microarray analysis was performed on 32 head and neck keratinocytes cultures using Affymetrix U133A/B genechips. The panel of cultures included normal cells, mortal and immortal cultures of dysplastic keratinocytes and mortal and immortal cultures from carcinomas, all grown to a standard protocol. …
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Analysis of populations within the UAE using tandem repeat DNA markers
… a number of forensic and paternity parameters, including matching probability, discrimination power, probability of paternal exclusion and typical paternity index in order to assess the application of these two systems for forensic and paternity tests in the UAE. The five VNTR loci and eight STR …
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Biomarker development for gastrointestinal and ovarian cancer: a proteomic approach
The development of new biomarkers for cancer patients would be advantageous in population screening for the early detection of cancers, pathological diagnosis, assessment of prognosis, tailoring treatment to individuals, and assessment of treatment response. With this in mind different proteomic …
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Aberrant DNA methylation as a diagnostic and predictive marker of ovarian cancer
… silencing of key tumour suppressor genes in cancer and is a frequent epigenetic event in epithelial ovarian cancer (EOC). The methylation status of 24 CGIs in a retrospective group of 142 EOCs and 16 non-tumour adjacent tissues were analysed using methylation-specific PCR (MSP) and Combined …
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A study of keratinocyte differentiation and adhesion in vitro
In this study, I used the serum-free MCDB 153 culture system to investigate calcium-induced keratinocyte differentiation. Treating normal human keratinocytes with high extracellular calcium concentrations (1mM) increased the proportion of cells expressing differentiation-specific proteins. I showed …
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Identification of proteins interacting with the human mismatch repair protein MLH1
… of c-MYC, which is associated with many cancers, may result in the sequestration of hMLH1 preventing functional MMR. The interaction between hMLH1 and c-MYC is proposed to act in a DNA damage response pathway which is disrupted upon aberrant c-MYC expression.
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The molecular pathology of BRCA1 and BRCA2 in breast cancer patients from the West of Scotland
Abstract available p. i-iii
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Immunotherapy in multiple myeloma
The BDCA antibodies allowed reliable measurement of dendritic cell (DC) subsets and B cell numbers in the blood of normal subjects, and patients with MM throughout the disease course. The numbers of blood myeloid DC (BmDC) and blood plasmacytoid DC (BpDC) are low throughout the course of the …
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The role of p53 in virus-induced and multi-step lymphomagenesis
It has previously been demonstrated that p53 loss and Moloney murine leukaemia virus (MMLV) infection are weakly collaborative in T cell lymphomagenesis. The work described in this thesis aimed to investigate the role of p53 in MMLV-induced lymphoma and explore the basis of their relatively weak …
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Cyclic AMP modulation and its effects on chemo-resistant colon cancer cell proliferation and survival
… of the major problems associated with colorectal cancer is resistance to cytotoxic chemotherapeutic agents. New strategies are therefore required to inhibit colon cancer proliferation and survival. Here I use modulators of cAMP pathways, including inhibitors of phosphodiesterase 4 (PDE4) enzymes, …
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E2F1 induction following DNA damage and oncogene activation
… suppressor pRb, is deregulated in most human cancers. Oncogenes have been shown to deregulate E2F1 through inhibition of pRB and deregulation of E2F1 is an event that occurs in most human cancers. The essential role of E2F1 in apoptosis is well documented and deregulated E2F1 can enhance drug …
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Identification and validation of Biomarkers for Breast Cancer from human White Blood Cells
… prognosis and treatment efficacy of breast cancer. Peripheral white blood cells (WBCs) carrying the information related to the presence of cancer, represent an attractive source for novel biomarkers. The main aims of the study were to develop the pipeline to discover and validate novel …
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The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
… immunogenicity and immunoediting of breast cancer cells. To investigate the interaction of CD74 with CD44 and MIF, confocal microscopy and co-immunoprecipitation techniques were used. The three molecules form a multimeric complex in cytoplasmic compartments as measured by confocal …
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Second cancers following treatment for retinoblastoma
… have elevated risks of developing additional cancers, mostly bone and soft tissue sarcomas and melanoma. Despite advances in understanding of second cancer risks following treatment for retinoblastoma, key research questions remained including 1) risks of common adult onset cancers, some of …
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Can Intensity-Modulated Radiotherapy (IMRT) Be Used To Reduce Toxicity And Improve Tumour Control In Patients With Head And Neck Cancer?
… commonly used in the treatment of head and neck cancer. For early stage tumours, conventional radiotherapy techniques have a high cure rate and low levels of long-term complications. Patients with more advanced cancers have much lower cure rates and high levels of treatment-related complications. …
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In vivo and in vitro studies of immunodeficiency in Ataxia-telangiectasia
… Immunodeficiency per se is not the cause of cancer in A-T but both immunodeficiency and cancer are consequences of the same basic ATM defect affecting the lymphoid system. There was no evidence of a role for ATM in NKG2D ligand upregulation following DNA damage.
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