Global ETD Search
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Showing 1 to 6 of 6 for “"RBPMS"”.
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Elucidating the structure-function relationship of the cell-type specific splicing regulator, RBPMS
… RNA binding protein with multiple splicing (RBPMS), regulates the alternative splicing programme in differentiated vascular smooth muscle cells (VSMCs). RBPMS has an N-terminal RNA recognition motif (RRM) that mediates both RNA binding and dimerization, allowing binding to pairs of …
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Identification of RBPMS as a smooth muscle master splicing regulator via association of its gene with super-enhancers
… RNA Binding Protein with Multiple Splicing (RBPMS) was identified as a critical splicing regulator in vascular smooth-muscle cells (SMCs). RBPMS is strongly downregulated during SMC dedifferentiation and is responsible for nearly 20% of the AS changes during this transition as indicated by …
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Phosphorylation of The Smooth Muscle Master Splicing Regulator, RBPMS-A, Regulates its Splicing Activity
We have previously identified RBPMS as a master regulator of alternative splicing in differentiated smooth muscle cells (SMCs), responsible for controlling numerous components critical to differentiated SMC function (Nakagaki-Silva et al., 2019). Therefore, the precise control of this splicing …
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Co-regulation of the Smooth Muscle Cell Alternative Splicing Programme by the RNA-Binding Proteins RBPMS, RBFOX2, MBNL1, and QKI
… extensive alternative splicing (AS) regulation. RBPMS, a master splicing regulator in differentiated VSMCs, is responsible for approximately 20% of AS changes observed during dedifferentiation in PAC1 VSMCs (Nakagaki-Silva et al., 2019). However, the cooperative and antagonistic relationships …
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Development of a Workflow to study Neuronal Injury In Vivo in the Retina and In Vitro in Collagen Hydrogels
… RNA Binding Protein with Multiple Splicing (RBPMS), revealed significantly fewer retinal ganglion cell (RGC) somas in the blast-exposed group than the sham group (P < 0.001). Nitrotyrosine, an indicator of oxidative stress, was elevated in the ganglion cell layer of the blast-exposed group. …
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Bioenergetic neuroprotection in experimental glaucoma
… variety of RGC specific immunolabels (Brn3a and RBPMS). Our results demonstrate excellent accuracy and a 40-fold reduction in time compared to manual counting. Ultimately this software promises to expedite data acquisition and statistical analysis in pre-clinical glaucoma neuroprotection …