Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"RBP"”.
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RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1
… dependent on the interaction of P48 with either RBP-J, or its paralogue, RBP-L. The exclusive form of PTF1 in mature pancreatic acinar cells is a potent transcriptional activator containing RBP-L; however, RBP-J can form a similar, but low activity, complex. The P48-RBP interaction is primarily …
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RBP-J dependent and independent signalling of EBNA-2
… by cellular DNA-binding proteins, such as RBP-J and PU.1, since EBNA-2 does not contain its own DNA-binding domain. In order to better characterise EBNA-2 signalling we conducted a mutational analysis of the viral LMP-1 promoter that is strongly induced by EBNA-2 in the EBV-immortalised …
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TB-RBP protein : sitting at the crossroads of sex and disease
… was to determine the crystal structure of TB-RBP (Testis/Brain RNA binding protein) in complex with single stranded DNA. The secondary goal was to determine the crystal structure of TB-RBP in complex with Trax (translin associated factor X). Functions of TB-RBP is to suppresses translation of …
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The Interactions for the RBP Receptor, Stimulated by Retinoic Acid Gene 6
… and immunocompetence. Retinol binding protein (RBP) is the principal carrier of retinol in the blood from its storage site, the liver, to retinol dependant tissues. The long sought RBP receptor was recently identified as stimulated by retinoic acid gene 6 (STRA6), a 74 kDa multitransmembrane …
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Computational analysis of cooperation and competition mechanisms between RNA-binding proteins
… forming this network, RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation of gene expression (PTR). Understanding RBPs behavior is therefore crucial given their participation in all stages of the mRNA life cycle. Although an increasing amount of work has highlighted …
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The effect of Retinol Binding Protein on the Proteome of muscle cells.
… development and vision. Retinol binding protein (RBP) and its receptor, STRA6, are vital for the maintenance of intracellular stores of vitamin A. Recently, elevated serum RBP concentration has been implicated as a contributing factor to the development of insulin resistance and type II diabetes. …
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Possible Interacting Proteins for Retinol Binding Protein and Cellular Retinol Binding Protein
… system attached to Retinol Binding Protein (RBP) and its transport into the cell is mediated by the RBP receptor STRA6. Inside the cell, retinol binds to cellular Retinol Binding Protein (CRBP) and can be converted to retinoic acid, which can then act as a regulator of transcription. High …
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Developmental and estrogen regulation of Xenopus laevis retinol-binding protein gene expression
… been examined. Serum retinol binding protein (RBP) mRNA is detected exclusively in liver tissue in both adult Xenopus laevis and in tadpoles. RBP mRNA is absent in Xenopus oocytes and is present at extremely low levels in early embryos. The developmental activation of constitutive RBP gene …
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Complex Regulation of Pax6 Neuronal Progenitors By Rb Family Members During Corticogenesis
… Rb promoter during corticogenesis, we generated RbP-LacZ lines in genetic backgrounds deficient in various Rb family members and looked for deregulation of RbP-LacZ activity within the embryo (Aim 1). Surprisingly, RbP-LacZ activity responds in opposing ways with either loss of Rb or dual loss of …
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Cloning and Estrogen Regulation of the Retinol Binding Protein Messenger-Rna of Xenopus Laevis
… vitellogenin in that: (1) estrogen induction of RBP mRNA is very long-lived, (2) the persistent elevated abundance is dependent on estrogen receptor, and (3) that the estrogen induction is antagonized by testosterone. In addition to the regulation of the gene's expression imposed by hormones, I …
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The Effects of Nutrient Concentrations on Macroinvertebrate Distributions in Georgia
… using the EPA's rapid bioassessment protocol (RBP). The concentrations of nutrients were measured in mg/L and ranged as follows: nitrite and nitrite/nitrate < 0.01 to >1.0, ammonia < 0.03 to 3.0, and phosphorous < 0.01 to 1.2. Analysis determined (1) the RBP has the potential to indicate …
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Adaptive Intelligent User Interfaces With Emotion Recognition
… [MBP], and Resilient Backpropagation [RBP]) were implemented to analyze the collected data signals and to find unique physiological patterns of emotions. Emotion Elicitation with Movie Clips Experiment was conducted to elicit Sadness, Anger, Surprise, Fear, Frustration, and Amusement …
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Genome engineering and functional gene regulation tools for the study of malaria parasites
… function of an essential RNA-Binding protein (RBP). We first determined the essentiality of our target protein using a two-step approach, in which a merodiploid line conditionally expresses an ectopic copy of the RBP and the native gene is disrupted using CRISPR technologies. This approach was …
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Knowledge creation in a cross cultural context for sustainable organisational change and development
… in accession such as the Romanian Border Police (RBP). The need for organisations to expand their knowledge of strategic decision making for change and development resulted in a plethora of EU-funded training interventions to fill the gap. The literature suggests that as a result of the dominance …
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Comparing Reef Bioindicators on Benthic Environments off Southeast Florida
… the Stony Coral Rapid Bioassessment Protocol (RBP) was conducted to determine coral cover and selected other parameters. During sampling, 29 surface sediment samples were collected that I analyzed with respect to sediment texture, foraminiferal assemblages, and sediment constituents. Most …
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Assembling The Building Blocks For A Unified Splicing Code
… regulators known as RNA-binding proteins (RBP). The second involves predictive models, also known as splicing codes, which infer regulatory mechanisms and predict splicing outcomes directly from genomic sequences. In this dissertation, we try to gain a better understanding of splicing …
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Biochemical and functional characterization of human RNA binding proteins
… approximately one thousand RNA binding proteins (RBPs) that direct RNA splicing, cleavage and polyadenylation, localization, translation, and degradation. Despite the central role of RBPs in RNA processing and gene expression, they have been less well studied than DNA binding proteins, in part due …
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Investigating the Role of RNA-Binding Proteins in Tumor Response to DNA Damage-Inducing Chemotherapy
… studies indicate that RNA-binding proteins (RBPs) appear to play a particularly important role in cancer, and may contribute to chemoresistance, but the field is still at an early stage and nothing has yet progressed towards translational utility. This is at least partially due to a lack of …
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Reliable Neighborcast Protocol for Vehicular Ad hoc Networks
… recently invented reliable broadcast protocol, M-RBP, and transfers the guarantees provided by the modified M-RBP from the broadcast group level to the neighborhood level. RNP is composed of two parts. The first is the self-organizing protocol that organizes vehicles into overlapping broadcast …
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