Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"RBFOX2"”.
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Multiple regulatory layers in the establishment of Rbfox2 splicing networks
… UGCAUG. We sought to comprehensively define the Rbfox2 splicing regulatory network and discover determinants of Rbfox2 regulation in mouse embryonic stem cells. We uncovered fundamental principles in the mechanistic aspects of Rbfox-dependent splicing and in the systems-level regulation of …
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CELF1, PTBP1, and RBFOX2-mediated alternative splicing regulation in cardiovascular diseases
… RNA binding proteins (RBPs) CELF1, PTBP1, and RBFOX2 contribute to AS changes. Utilizing genome-wide approaches, we identified extensive changes in AS patterns in T1D mouse hearts. We discovered that many aberrantly spliced genes in T1D hearts have CELF1 and PTBP1 binding sites. CELF1-regulated …
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Mechanisms of Dysregulated Alternative Splicing in Cardiac and Skeletal Muscle under Diabetic Conditions
… controls RNA-binding proteins (RBPs) CELF1 and RBFOX2 that are involved in developmentally regulated AS in the heart. Since PKC is chronically activated in diabetes, we hypothesized that aberrant PKC activity alters CELF1 and RBFOX2 and disrupts AS. To test this hypothesis, we performed …
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Co-regulation of the Smooth Muscle Cell Alternative Splicing Programme by the RNA-Binding Proteins RBPMS, RBFOX2, MBNL1, and QKI
… remain unclear. In this study, I investigated RBFOX2, MBNL1, and QKI as potential co-regulators of RBPMS in VSMC AS regulation. RBFOX2 was identified as a key candidate due to enrichment of its GCAUG binding motifs around RBPMS-regulated exons in positions suggesting cooperative regulation. …
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Régulation de l’épissage alternatif par un complexe de facteur d’épissage et annotation fonctionnelle de l’épissage alternatif
… se liant au RNA (RBPs) entre d’autres facteurs. RBFOX2 est un tel RBP régulant l'épissage dans les tissus sains et cancéreux. Il est proposé que RBFOX2 régule l'épissage des cibles sans son motif canonique par la liaison indirecte médiée par un autre régulateur d'épissage dans le cadre d'un …
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Understanding regulation of mRNA by RNA binding proteins
… the developmentally-regulated splicing factors RBFOX2, MBNL1 and CELF1/CUGBP1. For each factor, the canonical motifs are recovered as well as additional near-optimal binding motifs. RNA secondary structure inhibits binding of RBFOX2 and CELF1, while MBNL1 favors unpaired Us but tolerates C/G …
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Concentration-dependent Splicing through Suboptimal Motifs Enables Waves of Gene Regulation in Neuronal Development
… and neuronal contexts. We incubated recombinant RBFOX2 with over 60,000 mouse and human transcriptomic sequences to reveal substantial binding to several moderate-affinity, non-GCAYG sites at a physiologically relevant range of RBFOX2 concentrations. We find that these “secondary motifs” bind …
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NF-YA ISOFORMS ROLES IN CLAUDIN LOW CANCERS
… driving NF-YA alternative splicing, among which RBFOX2, QKI and CELF2 both in BRCA and in STAD cell lines. Through transient overexpression, I validated RBFOX2 as splicing factor promoting the maturation of NF-YAl. Finally, through a frameshift mutation in NF-YA gene, I have investigated the …