Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"RBE"”.
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Μικροδοσιμετρικά μοντέλα υπολογισμού του RBE στην αδρονιακή θεραπεία με έμφαση στο μοντέλο RMF / Microdosimetric models for RBE calculation in hadron therapy: focus on the RMF model
… υπολογίζονται παραμετροποιημένες σχέσεις για το RBE (για βιολογικό αποτέλεσμα DSB) ως συνάρτηση της ποσότητας (Zeff/β)2, η οποία περιγράφει χαρακτηριστικά του ιόντος. Επίσης ήταν αναγκαίο να υπολογιστεί η παράμετρος zF. Στην παρούσα εργασία υπολογίστηκε η γραμμιώδης και ειδική ενέργεια με την …
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Ανάλυση βάσεων δεδομένων για το RBE ακτίνων-Χ, ηλεκτρονίων και αδρονίων
… προσδιοριστεί με δύο διαφορετικούς ορισμούς το RBE, ηλεκτρονίων και πρωτονίων σε ανθρώπινα κύτταρα, για διάφορα ποσοστά συγκέντρωσης οξυγόνου 100%, 20% (τυπική φυσιολογική οξυγόνωση) και 1% (υποξία) και να πραγματοποιηθεί η μεταξύ τους σύγκριση. Χρησιμοποιήθηκε ο κώδικας Monte Carlo Damage …
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Biblioteca escolar : à procura da sua acção pedagógica : uma visão sobre o percurso de bibliotecas escolares integradas na RBE
Questionamos, neste estudo, se a acção pedagógica das bibliotecas escolares tem correlação na acção educativa da escola. Dá-se conta da revisão da literatura em áreas como o novo paradigma de educação que vai emergindo, a gestão do conhecimento, a qualidade e eficácia das escolas enquanto …
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Modeling Proton Relative Biological Effectiveness Using Monte Carlo Simulations of Microdosimetry
… an enhanced relative biological effectiveness (RBE) compared to photons. In the current clinical standard, RBE is fixed at 1.1 at all points along the proton beam, meaning protons are assumed to require 10% less dose than photons to achieve target coverage and organ at risk (OAR) sparing. …
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As escolas e o Programa Rede de Bibliotecas Escolares : um estudo sobre os processos de desenvolvimento das bibliotecas integradas na RBE
… integradas na Rede de Bibliotecas Escolares (RBE) Num primeiro momento, apontamos algumas das linhas de força que caracterizam a actual sociedade de informação, para uma melhor contextualização da missão e objectivos das bibliotecas escolares. Fazemos o levantamento de alguns dos mais …
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Uncertainty In The Physical Basis of Estimates of Relative Biological Effectiveness In Carbon Radiotherapy
… is the relative biological effectiveness (RBE) of the beam (i.e., how biologically potent carbon ions are as compared to x-rays), which is significantly elevated. This RBE also varies as a function of many parameters, and there are currently several models implemented in clinical and …
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Evaluation of Radiobiological Effects in Intensity Modulated Proton Therapy : New Strategies for Inverse Treatment Planning
… of the relative biological effectiveness (RBE). To investigate the potential clinical relevance of a variable RBE for beam scanning techniques, new strategies for the evaluation of radiobiological effects and for the incorporation of the RBE into the inverse planning process are presented. …
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Assessing The Potential Clinical Impact of Variable Biological Effectiveness In Proton Radiotherapy
… protons a relative biological effectiveness (RBE) value of 1.1 corresponding to 10% increased effectiveness compared to photon radiation. Numerous studies have shown, however, that the RBE value of protons is variable and can deviate substantially from 1.1, but experimental data on RBE and …
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Quantifying Uncertainty In A Measurement-Based Assessment of Relative Biological Effectiveness In Carbon Ion Radiotherapy
… in relative biological effectiveness (RBE), a value that is calculated via one of several clinically implemented algorithms. This study investigates the uncertainty in measured microdosimetric parameters for RBE calculation by the Microdosimetric Kinetic Model (MKM), Repair Misrepair …
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Enhancement of anti-HIV-1 Ribozyme Activities by Rev Binding and Multimerization
… transcript termed the Rev Binding Element (RBE). In anti-HIV gene therapy employing ribozymes to increase the co-localization of anti- HIV ribozymes with target HIV mRNAs, it has been proposed that when the native HIV- 1 RBE is appended to a ribozyme as a decoy molecule, simultaneous binding …
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Analysis of Protein and RNA Interactions of the HIV-1 rev Protein
… of the RRE, known as the Rev Binding Element (RBE), has previously been shown to inhibit HIV-1 replication <em>in vivo.</em> The specific interaction of such molecules with Rev is necessary for their usefulness as therapeutics. We have found that RBE aptamers evolved by SELEX interact …
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Biological dosimetry of neutron beams for neutron capture therapies
… combined biological and physical dosimetry interbeam comparison data of three neutron beams used in boron neutron capture therapies: the Massachusetts Institute of Technology (MIT) and Brookhaven National Laboratory epithermal neutron beam facilities previously used in Phase I/II human clinical …
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Real-time Prediction of Dynamic Systems Based on Computer Modeling
… vehicle system a novel parallel grid-based RBE technique is firstly proposed. The formulations are derived by identifying the parallel computation in the prediction and correction processes of the RBE. A belief fusion technique, which fuses not only the observation information but also the …
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High-Throughput Mapping of The Biological Effects of Particle Therapy
… specific relative biological effectiveness (RBE) when compared to photons. It is essential to employ accurate biophysical models for particle beams in order to maximize the therapeutic potential of particle therapy through the introduction of biologically optimized treatment planning. The …
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Towards measuring the relative biological effectiveness of high-energy neutrons at iThemba LABS
… the neutron Relative Biological Effectiveness (RBE). The current deficiency of experimental data regarding the biological effects of high-energy neutrons calls for dedi-cated RBE experiments at neutron energies greater than 20 MeV for the doses, dose rates, and biological endpoints that are …
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Challenging the Rigor of Alpha/Beta and Relative Biological Effectiveness in Tumor Contorl [sic] Probability Determinations via In Silico Modeling That Incorporates Individualized Biological and Physiological Data
… of relative biological effectiveness (RBE) values for charged particles is based upon the survival response of a very limited number of mammalian cell lines. Such potential discrepancies in the determination, or even the utility of, the LQ parameters and RBE values may negatively impact …
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Establishment of the Physical and Technical Prerequisites for the Determination of the Relative Biological Effectiveness of Low-energy Monochromatic X-rays
… about the relative biological effectiveness (RBE) of soft X-rays can be made due to its dependence on the photon energy, biological endpoint and dose range and the consequent large spread of the published data. The superconducting electron linear accelerator of high brilliance and low …
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Improving Dose-Response Correlations For Locally Advanced Nsclc Patients Treated With Imrt Or Pspt
… of variable relative biological effectiveness (RBE), would lead to statistically and clinically significant improvement in the correlation of RP with biologically effective dose distributions.</p> <p> Our work resulted in a robust intra-4DCT and inter-4DCT DIR workflow, with the accuracy meeting …
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Scanned Ion Beam Therapy For Thoracic Tumors
… greater relative biological effectiveness (RBE) for cell sterilization in a target but nearly equivalent RBE in tissue upstream of the target, compared to proton therapy. Thus, we expected that for some patients with Hodgkin lymphoma, carbon-ion therapy would reduce the predicted risk of …
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As bibliotecas escolares e as (novas) tecnologias na promoção da leitura: distrito de Setúbal
… da Rede de Bibliotecas Escolares (RBE), aplicados em 2015 e em 2017 aos professores dos Agrupamentos de escolas do Distrito de Setúbal, integrados na RBE. Trata-se de um estudo de caso, de cariz qualitativo, com caráter descritivo e analítico. Verificou-se que mais de um quarto dos …
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