Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"RB Pathology"”.
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Studies on human serum cholinesterases
Abstract p. iv-vi
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Regulation of CD74 expression in response to Human Interferon Gamma and Lipopolysaccharide on Human Trophoblast Derived Cells: Relevance for Human Feto-Maternal Tolerance.
During pregnancy, the maternal immune system protects the allogeneic foetus from rejection. At the same time the mother maintains immunity defences against potential pathogens. This study aimed to identify whether immunological receptors associated with antigen presentation and strong inflammatory …
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Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins
GPVI activates platelets through an ITAM pathway by activation of Src and Syk kinases leading to activation of PLC\(_y\)2. CLEC-2 has been shown to activate platelets using an ITAM-like sequence in its cytoplasmic tail that is also dependent on Src and Syk kinases, but shows a partial rather than …
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Phenotypic and functional analysis of organ specific endothelial cells
All classes of leukocytes must be able to move from the circulation into tissue to carry out their protective functions. To achieve this transfer, the flowing cells must adhere to the endothelium and migrate through the vessel wall. Though this process follows common stages during recruitment in …
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A Bioinformatics Analysis of Bacterial Type-III Secretion System Genes and Proteins
Type-III secretion systems (T3SSs) are responsible for the biosynthesis of flagella, and the interaction of many animal and plant pathogens with eukaryotic cells. T3SSs consist of multiple proteins which assemble to form an apparatus capable of exporting proteins through both membranes of …
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Fibroblast Regional Identity in the Murine Lymphoid System
Fibroblasts are the most abundant cell type of the stroma, producing extracellular matrix components which provide mechanical strength to tissues. Recent work has shown that fibroblasts are not simply passive structural cells but active participants in the immune response. In this study fibroblast …
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Acute tubulo-interstitial nephritis : clinical profile and pathogenic mechanisms
… (ATIN) is an important cause of renal morbidity. This study showed that it represents up to 8% of acute renal failure where biopsy material was available and accounted for 1% of all renal biopsy material. This study, which is believed to be the largest single retrospective study carried …
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Molecular events governing hematopoietic stem cell recruitment in Vivo in murine liver following Ischemia-reperfusion injury
Evidence suggests haematopoietic stem cells (HSCs) can migrate to injured liver and influence tissue repair. However, the molecular adhesive mechanisms governing HSC recruitment to injured hepatic microcirculation are poorly understood. These mechanisms were investigated in vivo following murine …
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Ambulatory diagnosis of endometrial pathology
The aim of this thesis was to determine the diagnostic accuracy of outpatient endometrial evaluation using endometrial biopsy (EB), ultrasound scan (USS) and hysteroscopy (OPH) by conducting systematic quantitative reviews of the published literature. The optimum diagnostic strategy in terms of …
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The role of EGFR, HER 2-4, heregulin and downstream signalling in prostate adenocarcinoma
Background Currently evidence regarding influence of the HER tyrosine kinase family - EGFR, HER2, HER3 and HER4 - during disease progression in prostate adenocarcinoma is conflicting – both poor prognosis and no influence on outcome are reported. A small cohort pilot study of paired hormone …
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A computer model for investigating the biomechanical effects of radiation exposure on pathological and non-pathological living human cells
The cellular response to radiation insult and studies have been carried out to investigate aspects of the cytoskeleton and the force response of the cell when probed by an AFM. Confirmed for the first time that there was a statistically significant difference for the PNT2 and PC3 cell lines in …
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Investigating the functional significance of the upregulation of Cyclin D2 and p21 following Apc loss in vivo
The Apc gene encodes the Adenomatous polyposis coli tumour suppressor protein, the germ line mutation of which characterizes Familial Adenomatous Polyposis (FAP), an autosomal syndrome characterized by multiple colorectal lesions. Inactivation of the Apc gene is recognized as a key early event in …
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Analysis of soluble high-affinity PD1 variants
Despite achieving significant clinical impact in several major cancer types such as melanoma or Hodgkin’s lymphoma, immunotherapies have not had much success in the treatment of pancreatic cancer. This cancer is characterised by a pro-inflammatory and immunosuppressive stroma which causes …
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The role of platelets and their associated recruitment mechanisms, in intestinal ischaemia reperfusion injury
… may prove beneficial in improving the clinical morbidity associated with gut IR injury.
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The detection of drugs of abuse in biological matrices using enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry
The aim of this study was to investigate the potential use of ELISA and LC-MS-MS in combination and as individual techniques, for the detection of drugs of abuse in biological matrices. Overall the LC-MS-MS method showed good correlation results for opiates compared to the GC-MS method. 6-MAM was …
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Lymph node metastasis in auricular squamous cell carcinoma
… 1992 - 2004. 212 of these cases had the primary pathology available for analysis. 24 (of 212) patients developed metastasis. 17 patients died as a result of their disease usually due to failure of control at the regional lymph node basin. Primary tumours with a depth of invasion greater than 8mm …
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The pathogenesis of classical Hodgkin lymphoma : investigation of possible viral pathogens and recurrent chromosomal imbalances
Hodgkin lymphoma (HL) is a malignant lymphoma that is diagnosed mostly in young adults, and is the second most common malignancy to affect this age group. This disease is subdivided into two entities with different aetiologies: classical HL (cHL) (~95% of cases) and nodular lymphocyte-predominant …
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Effects of IL-33 on the interaction between HMC-1 cells and human airway smooth muscle cells
… processes are characteristic of the disease pathology including; airway remodelling, airways hyperreactivity and airways inflammation. The interaction of mast cells and human airway smooth muscle (HASM) cells play an important role in the characteristic pathological processes involved with …
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The role of virus neutralisation in immunity to feline immunodeficiency virus infection
Feline immunodeficiency virus (FIV) is an important veterinary pathogen with comparative significance because of its similarities to its human counterpart HIV. Since FIV is the only non-primate lentivirus which induces AIDS-like symptoms in its natural host, it serves as a valuable animal model for …
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Targeted gene therapy for canine osteosarcoma: preliminary investigations
Osteosarcoma (OS) is the most common bone cancer in dogs. It is biologically aggressive and <20% survive >2 years with standard therapy. Hence, new approaches must be considered. TP53 is altered in ~50% of human and canine cancers, including OS, making it a candidate for targeted suicide gene …
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