Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"RASA1"”.
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Studies on the Molecular Mechanisms of Tumorigenesis in Neurofibromatosis Type 1
… NF1 cells. Interestingly, we observed lower RASA1 gene expression in the malignant cells compared to normal and benign cells in both mRNA and protein levels by RT-PCR and Western blot analysis. RASA1 gene encodes p120RasGAP, which is first described as a negative regulator of Ras in 1988. To …
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Molecular Genetic Analysis of Tumor Cells and Developmenet of RNA Interferance Therpy in Neurofibromatosis Type1(NF1)
… the decreased expression level in the NF1 and Rasa1 genes were responsible for the tumorigenesis and malignant degeneration in this NF1 case. Furthermore, this previously unrecognized Ras and Rasa1 regulatory mechanism may be exploited therapeutically. RNA interference (RNAi) is a newly …