Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"RAS mutations"”.
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blmp-1 is a Ras-cooperating Tumor Suppressor Gene in Caenorhabditis elegans
While hypermorphic Ras mutations are found in approximately 35% of colorectal, 45% of lung and 90% of pancreatic cancers, activated Ras alone is not sufficient to transform normal cells into cancerous tumors. Additional driver mutations or epigenetic alterations are required to cooperate with the …
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Collagen gene expression in human cancer
… mRNA levels compared to Dukes A and B. Mutated Ras has been shown to affect collagen mRNA levels in vitro (Slack et al, 1992), therefore the colon samples were analysed for Ras mutations in an attempt to correlate Ras mutations with the decreased levels of α1(I) and α2(I) collagen mRNA. …
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The role of ras signaling associative learning and memory in Drosophila
Ras is an evolutionally conserved signaling molecule that has been implicated in a variety of cellular events, such as cell proliferation, differentiation, and survival. Recent studies also suggest roles of Ras in neuronal plasticity. I investigated the role of Ras in associative learning and …
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The disordered N-terminus of RLIP76: a hub for protein and membrane interactions
… Ral proteins are themselves downstream of Ras, and Ras mutations drive around 20% of all cancers. RLIP76 has been implicated in a number of cell processes ranging from receptor mediated endocytosis, to mitochondrial fission and metabolite transport. Despite implications in multiple …
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Systems analysis of cytokine mediated communication and signaling
… in the context of a variety of genetic Ras mutations, we identify clear differences between signaling from N-Ras and K-Ras isoforms, and identify isoform specific contributions to intestinal apoptosis. The next part of this work focuses on understanding cytokine secretion from primary …
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The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity
… neoplasms associated with activating mutations in signalling pathway molecules and a variable tendency to develop acute myeloid leukaemia (AML). This thesis examined genotype-phenotype associations of JAK2 and MPL mutations, the presence of clonal diversity in the MPD and the genetic …
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Discovery of the First Endogenous Gain of Function Mutation in Drosophila RAS1 as a Dominant Suppressor of Apoptosis
… that this mutant is a gain-of-function allele of ras85D (ras1), the Drosophila homolog of mammalian oncogenes H-ras, K-ras and N-ras. We further establish that this viable allele, rasR68Q, contains a mutation in the Switch II region of Ras and that it produces a GTPase protein with diminished …
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Ras Intrinsic and Extrinsic Pathways in Human Cancer
<p>The Ras family of proteins, composed of H, N, and KRas, function as small GTPases that act as "molecular switches" relaying signals from the cell membrane to the rest of the cell in a highly regulated manner. However, Ras signaling is aberrantly activated in a majority of human cancers either …
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Role of Cell Death Regulatory Genes and Radiation Response in Pancreatic Adenocarcinomas
… governing growth inhibition and apoptosis. Mutations in the ras oncogene that(activate ras) are known to lead to the inactivation of genes that are directly involved in these pathways of growth inhibition and apoptosis. Oncogenic activated ras inhibits TGF-P signalling through the …
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Genomic Characterization of Adolescent and Young Adult Cancers: Investigation of Ewing Sarcoma Susceptibility and Chornobyl Thyroid Tumors
… 22q deletion acts potentially as a cofactor with RAS mutations in PTC tumorigenesis, mediated through immune-related disruption. The findings in this dissertation describe unique genomic features present in AYA cancers and unravel the complex interplay of molecular and epidemiological …
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Structure Based Drug Design of High Affinity Kras Inhibitors
<p>RAS, one of the most well characterized membrane-associated small GTPases, is a notorious oncogene with >15% of all tumors harboring RAS mutations. When RAS is mutated it becomes constitutively active sending cell growth, survival and proliferation into overdrive, which subsequently leads to …
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
… used hydrodynamic tail vein (HDTV) delivery of NRASG12V-containing transposons in mice, to model hepatocyte oncogene-induced senescence (OIS) combined with multiple downstream assays to interrogate four elements of adaptive senescence surveillance: functionality of T-helper subsets; their …
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Molecular signatures underlying the tumourigenic transformation in a CEBPA mutated model of leukaemia
… studies have enabled the identi- fication of mutations and chromosomal rearrangements frequently found in Acute Myeloid Leukaemia (AML). However, understanding the individual and synergistic impacts of these aberrations on the development of disease is challenging due to the vast clinical and …
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Epidermal growth factor and Transforming growth factor α motogenic activities are mediated by Epidermal growth factor receptor : Identification of signalling pathways involved in head and neck cancer
… with the genetic lesions to EGFR mutation and Ras mutations. These mutations are more common in Asian than Caucasian patients. More recently the Tyrosine kinase inhibitors (Gefitinib and Erlotinib) have been investigated as drugs to target tumours with EGFR mutation. These inhibitors bind to …