Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"RAS Oncogene"”.
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Activation of the c-Ha-ras oncogene
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 1984
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Structure Based Prediction of Drug-Protein Interactions At Allosteric Sites: to wards Direct Inhibition of The Ras Oncogene
<p>Ras is a monomeric G-protein that mediates multiple signaling pathways. When bound to GTP, Ras binds to and activates effectors and when bound to GDP it does not. Somatic mutations occur in ~15% of all human cancers and cause Ras to be predominantly bound to GTP. Recently, several studies …
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Study of Mutations and Expression of Genes Correlated to the Appearance of Colorectal Cancer /// Проучване на мутации и експресия на гени, корелиращи с изявата на колоректален карцином
… study was to analyse the mutational profile of RAS oncogene correlated to the expression levels of genes related to energy metabolism, hypoxia and genomic stability, as well as the expression levels of microRNAs and their role in regulating the previously mentioned signalling pathways in …
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Gene mutations and expression in breast cancer
… is a multigenic disorder with mutations in oncogenes and tumour suppressor genes playing an important role in cellular transformation and ultimately in tumour formation. In this study, 40 breast cancer patients from the Western Cape province in South Africa and 4 breast cancer cell lines …
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ΟΙ ΣΥΝΕΠΕΙΕΣ ΤΗΣ ΕΚΦΡΑΣΗΣ ΤΗΣ ΠΡΩΤΕΙΝΗΣ Ρ21 ΓΟΝΙΔΙΑΚΟΥ ΠΡΟΙΟΝΤΟΣ ΤΟΥ ΟΓΚΟΓΟΝΙΔΙΟΥ Η-RAS1 ΚΑΤΑ ΤΗΝ ΚΑΡΚΙΝΟΓΕΝΕΣΗ
… A MODEL SYSTEM TO DETECT THE PRESENCE OF RAS P21 IN THE SERA OF BALB/C MICE CARRYING TUMOURS INDUCED BY MOUSE CELL-LINE TRANSFORMED BY THE HA-MUSV AND THE PRESENCE OF F-MLUV BY ELISA TEST. THE ELAVATED LEVELS OF RAS P21 WAS EXAMINED IN THE SERA OF CANCER PATIENTS ALSO. ONLY IN 3OUT OF 13 …
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Ferroptosis: A Novel Form of Cancer Cell Death Induced by the Small Molecule Erastin
… cancer cell death induced by the small molecule erastin. Erastin is a quinazolinone derivative that was originally identified in a screen for small molecules that are synthetic lethal with the RAS oncogene. In cancer cells with oncogenic RAS-RAF-MEK signaling, erastin induces an iron-dependent, …
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Ενεργοποίηση του ογκογονιδίου ha-ras1 του ανθρώπου από ογκογονίδια ιών και κυττάρων
THE H-RAS1 ONCOGENE IS A MEMBER OF THE RAS ONCOGENE FAMILY. RAS GENES ARE ACTIVATED IN APPROXIMATELY 50% OF HUMAN TUMOURS. THEREFORE, THE UNDERSTANDING OF THEMECHANISMS OF THEIR ACTIVATION IS CONSIDERED TO BE VERY IMPORTANT FOR THE PROGNOSIS, DIAGNOSIS AND THERAPY OF CANCER. THIS THESIS DESCRIBES …
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Enhancing Oncolytic Virotherapy Using Functional Genomic Screening
… and 23 across all three cell lines. Muscle RAS oncogene homolog (MRAS) emerged as a promising candidate following in vitro validation studies. To test the impact of inhibiting this gene in vivo, we engineered an oncolytic VV encoding a dominant negative of MRAS. The treatment of …
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Genome analysis: mutation analysis using near infrared laser-induced fluorescence (NIR-LIF) and single molecule detection in microfluidic devices
… unique advantage. DNA amplification via polymerase chain reaction (PCR) provides an unlimited supply of material for subsequent genetic analysis even in case where only a single copy of the DNA molecule is present in the sample. Research presented in this dissertation first examines the …
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Role of Cell Death Regulatory Genes and Radiation Response in Pancreatic Adenocarcinomas
… inhibition and apoptosis. Mutations in the ras oncogene that(activate ras) are known to lead to the inactivation of genes that are directly involved in these pathways of growth inhibition and apoptosis. Oncogenic activated ras inhibits TGF-P signalling through the down-regulation of RII …
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Regulation Of Cyclic-amp-dependent Protein Kinases During Skeletal Myogenesis
… myoblasts transformed by transfection of the Ha-ras oncogene.
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Exploring the Role of IL-1β/IL-1R in the Pathogenesis of K-ras Mutant Lung Cancer
… adenocarcinoma with driver mutations in the K-ras oncogene (KM-LUAD). KM-LUAD progression partly occurs through activation of the NF-κB pathway initiating an inflammatory response and creating a pro-tumor microenvironment. Notably, the pro-inflammatory cytokine IL-1β a potent activator and …
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Oncogenic roles of RAS in acute myeloid leukemia cooperated with Mll-AF9.
… mastocytosis was developed in Vav-tTA ; TRE-NRAS G12V transgenic mice without detectable other diseases. We assayed Vav-tTA -driven luciferase expression in hematopoietic cells including bone marrow-derived mast cells (BMMC) and CD34 positive hematopoietic progenitor cells (HPC) as well as …
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hCLCA2 IS A p53-REGULATED GENE REQUIRED FOR MESENCHYMAL TO EPITHELIAL TRANSITION IN BREAST
… the p53-dependent expression of an hCLCA2-luciferase fusion gene. Point mutation of the p53 consensus binding motif abolished this induction. Induction of hCLCA2 in MCF-7 cells by doxorubicin was inhibited by p53 knockdown and by p53 inhibitor pifithrin, indicating that p53 activates the …
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Microenvironmental and metabolic influences in tumor cell redox homeostasis
… important aspect of cancer cell biology, because oncogene-induced hyperproliferation results in pro-oxidant tumor cell phenotypes. Thus, tumor cell antioxidant systems are often inherently strained and vulnerable to further oxidative attack. Targeted therapies can be designed to kill tumor cells …