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Showing 1 to 20 of 39 for “"RAR"”.

  1. The Effect of HACE1 on RAR Protein Stability

    Payne, Erin J.Temple University. Libraries2011

    … (RA), as a ligand for retinoic acid receptors (RAR) and retinoid X receptors (RXR), modulates their transcriptional activity. The AF-1 and AF-2 domains mediate the transcriptional activity. The ligand dependent activation of the AF-2 domain by RA is well understood to involve chromosome …

    temple Repository record

  2. The roles of the retinoic acid receptors in growth, differentiation and development.

    Costa, Stacy Lara.University of Ottawa (Canada)2009

    … at the roles of the retinoic acid receptors (RARs) in differentiation by assessing their actions in the retinoic acid (RA) induced differentiation of P19 cells. I used mutant RARs to block the normal differentiation of these cells and then analyzed the possible mechanisms by which these …

    ottawa-retro Repository record

  3. RAR beta trans-repression of AP-1 transcription factor in HeLa cervical cancer cells : consequences on transcription of viral and cellular AP-1 controlled genes

    De Castro Arce, JohannaUniversität Heidelberg

    … cancer, the nuclear retinoic receptor ß2 (RARß2) gene is epigenetically modified and unable to be significantly induced. RARß2 can act as a tumor suppressor, since loss of its expression is associated with human tumor progression. One mechanism of RARß2-mediated growth inhibition is based …

    heid-diss Repository record

  4. EXPLORING THE PRE-LEUKEMIC PHASE OF ACUTE PROMYELOCYTIC LEUKEMIA: INSIGHTS FROM STUDIES OF SINGLE CELL ¿OMICS¿

    VILLA, EMANUELAUniversità degli Studi di Milano2025

    … (AML) driven by the oncogenic fusion protein PML-RAR, which acts as an aberrant transcription factor and blocks myeloid maturation at the promyelocyte stage. In vivo, the expression of PML-RAR is necessary but not sufficient for full-blown leukemia: knock-in (KI) mouse models of APL undergo a …

    milano Repository record

  5. Nachweis und Charakterisierung Retinsäure-bindender Proteine in der Fischretina

    Schütte, FrankUniversität Oldenburg

    … charakterisiert. Mit einem RA-Rezeptor (RAR)-Antikörper wurden mittels verschiedener immunchemischer Methoden membranassoziierte RAR-immunoreaktive Proteine nachgewiesen und deren Verteilung in der Retina charakterisiert. Schließlich wurde ein RA-bindendes und RAR-immunoreaktives und …

    oldenburg Repository record

  6. ROLE OF THE HISTONE DEMETHYLASE LSD1 IN THE REGULATION OF DIFFERENTIATION OF ACUTE PROMYELOCYTIC LEUKEMIA CELLS

    ROSSI, PIER LUIGIUniversità degli Studi di Milano2014

    … and in the majority of the cases, expressing PML-RAR fusion protein. PML-RAR works as a dominant negative counterpart of retinoic acid receptor (RAR) and represses its target genes by cooperating with many epigenetic regulators. Some of the known epigenetic enzymes involved in the APL pathogenesis …

    milano Repository record

  7. Molecular changes involved in oral cancer progression and their relevance to keratinocyte immortalisation

    Muntoni, AlessandraUniversity of Glasgow2002

    … loss of expression of retinoic acid receptor (RAR)-b and the cell cycle inhibitor, p16INK4a, p53 mutations and increased levels of telomerase/hTERT mRNA. In contrast, increased expression of the EGF receptor (EGF-R), known to be a characteristic of oral cancer, does not occur until after the …

    glasgow Repository record

  8. Elucidation of the Retinoid Signalling Pathway Involved in Axon Guidance in Lymnaea stagnalis and Xenopus laevis

    Rand, ChristopherBrock University2012

    … the nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), to mediate gene transcription. Moreover, RA has been shown to act as a guidance molecule for growth cones of regenerating motorneurons of the pond snail, Lymnaea stagnalis. Our lab has recently shown that RA can …

    brock Repository record

  9. Magreceptorok ligandkötési affinitásának vizsgálata FRET szenzorral

    Kovács, Dávid2017

    … az emberi retinsav alfa receptor (RAR) és retinoid x receptor (RXR) magreceptorok ligandkötési affinitását vizsgáltam a ligandkötő doménjük (LBD) konformációváltozása révén. Olyan DNS konstruktokat (plazmidokat) kellett létrehoznom, amelyekben a receptorok ligandkötő doménje …

    debrecen Repository record

  10. Inhibition of Retinoic Acid Receptors Results in Defasciculation of the Trigeminal Nerve in Xenopus laevis

    Thompson, Jeremy2018

    … nerve. Inhibition of retinoic acid receptors (RAR) results in trigeminal nerves that become unbundled or defasciculated in the eye region. To further understand how RA is affecting trigeminal development we searched for genes downregulated in response to RAR inhibition by the inhibitor BMS-453 …

    vcu Repository record

  11. The effects of luminance contrast, raster modulation, and ambient illumination on text readability and subjective image quality

    Wells, Emily JeanVirginia Tech1994

    … rated the 3:1 luminance contrast, the 1.2 RAR, and the 1000 lux ambient illumination conditions as possessing the lowest image quality. From this research, it can be concluded that 7:1 is the preferred contrast ratio. This conclusion is based upon the findings that the 3:1 and 7:1 luminance …

    vt Repository record

  12. Evaluating the importance of root abscission versus efflux to plant N-loss: consequences for plant N-isotope composition

    Packer, Kirsten FDepartment of Biological Sciences2018

    … NO₃- supplied at five relative addition rates (RAR) and in hydroponics with three physical disturbance regimes (direct aeration, aeration constrained within a pipe and circulation of nutrient solution through sand). The δ¹⁵N of roots and shoots, as well as the plant-derived N accumulation in …

    cape-town Repository record

  13. Cognitive Health in Black and Latina Midlife Women: The Role of Sleep and Vasomotor Symptoms

    Alexandra Paget-Blanc (22483042)2025

    … vasomotor symptoms (VMS), rest-activity rhythms (RAR), and memory performance in Black and Hispanic midlife women, thereby identifying potential midlife risk factors for cognitive decline and AD. Methods: Fifty-five peri- and postmenopausal Black and Hispanic women completed three consecutive days …

    uic

  14. Relationally-Autonomous Reasons as a Predictor of Collegiate Athletic Performance

    Katzman, Josef MaxEastern Kentucky University

    … between Relationally-Autonomous Reasons (RAR) and performance. Those in team sports were seen to be motivated more by RARs when compared to athletes in individual sports. </p>

    eku Repository record

  15. Identification and characterization of retinoic acid-induced morphological and electrophysiological changes in an invertebrate nervous system

    Vesprini, NicholasBrock University2012

    … nuclear receptors: the retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Recently, mounting evidence from many animal models has implicated a number of RA-mediated effects operating independently of gene transcription, and thus highlights nove~ nongenornic actions of RA. For …

    brock Repository record

  16. An investigation of novel therapeutic strategies for the treatment of multiple sclerosis and autoimmunity

    Gaunt, Christopher MichaelUniversity of Cambridge2020

    … to literature reporting that RXR ligands augment RAR agonists’ effect on murine Th17/iTreg cells. We show that bexarotene promotes the differentiation of human Foxp3+ iTregs from naive CD4+ T cells independent of RAR engagement, whilst concomitantly inhibiting the differentiation of Th17 cells and …

    cambridge Repository record

  17. The Effect of Retinoic Acid on Rai1 and Identification of Retinoic Acid Receptor Binding Site in Human Rai1

    Xue, Bingjie2019

    … nine strong retinoic acid response element (RARE) candidate sites upstream of the start codon in human RAI1. Since there are possible RARE sites present in the upstream sequence of RAI1, it is more likely that RAI1 is regulated by retinoic acid. However, further experimental evidence will be …

    vcu Repository record

  18. Regulation of Intestinal Epithelial Thymic Stromal Lymphopoietin Gene Expression by Retinoic Acid Receptor Alpha

    Mahmood, RamshaCumming School of Medicine2021

    … DCs numbers in the intestinal compartments of RARα-deficient mice (RARαvillin mice). We sought to generate an experimental system to identify signaling pathway(s) or mechanism(s) that might be governing these effects, specifically RA signaling, as this data suggested there might be contributing …

    calgary Repository record

  19. The stimulatory role of ICOS in the development of CD146+CCR5+ T cells co-expressing IFN-γ and IL-17 during graft-versus-host disease

    Liu, Liangyi2015

    … the major transcriptional factor of Th17, RAR-related orphan receptor gamma t (RORγt), could prevent the development of CD146+CCR5+ Tconvs in vitro. Our results demonstrate how pathogenic CD146+CCR5+ T cells are induced through ICOS or RORγt, suggesting new targets for GVHD treatment. We …

    iupui Repository record

  20. Quantifying soil reinforcement by fibrous roots

    Loades, K. W.University of Dundee2010

    … to both reinforcement and root area ratio (RAR), with a 6.7 ?1.40 kPa, or 190%, increase in shear strength between 0 and 950/m2. By 20 weeks in the field shear strength increased by only 29%. The glasshouse study showed an increase of 53%, with a positive correlation to planting …

    dundee Repository record

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