Global ETD Search
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Showing 1 to 5 of 5 for “"RAP80"”.
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Two Redundant Ubiquitin-dependent Pathways of BRCA1 Localization to DNA Damage Sites
… domains that BRCA1 indirectly interacts with RAP80, a ubiquitin-interacting protein. RAP80 targets BRCA1 to DSBs but whether or not RAP80 is the sole targeting subunit of the BRCA1 complex is a subject of debate. In my thesis, I generated somatic RAP80-/- cell lines and found that RAP80 is …
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Molecular Recognition At Dna Damage Sites
… focus of this dissertation is the BRCA1-RAP80 ubiquitin recognition complex, which is composed of five core constituents (RAP80, Abraxas, MERIT40, BRCC45, and BRCC36) and targets BRCA1 to the chromatin flanking DNA damage sites. Although this complex is required for BRCA1 chromatin …
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The identification and characterisation of proteins interacting with SUMO-ubiquitin hybrid chains
… SUMO-ubiquitin hybrid chain interacting protein RAP80 amongst the proteins identified as putative SUMO-ubiquitin hybrid chain interacting proteins. SUMO-ubiquitin hybrid chains are then evaluated in an in vivo context. A proximity ligation assay was developed to probe the association between …
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Uncovering Phosphorylation Circuitries that Control DNA Replication Fork Dynamics
… associated proteins. One such protein called RAP80 is a direct target of PPM1D. I demonstrate that PPM1D dephosphorylates RAP80 that triggers a change in a key replication protein called RAD51 promoting DNA synthesis. Specifically, PPM1D-RAP80 alters the association of RAD51 with DNA thereby …
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Phopsphorylation and Ubiquitin Modification At Dna Damage Sites In Response to Double-Strand Breaks
… sites. The A complex is comprised of BRCA1, Rap80, NBA1, BRE, BRCC36 and the adaptor protein Abraxas, which has been shown previously to constitutively interact with BRCA1-BRCT (BRCA1 C- terminal) domain through its C-terminal phosphorylated S406 residue. In this study, we found that DNA …