Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"RANTES"”.
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Genetische Assoziationsstudien der immunologisch relevanten Gene CCR5, CX3CR1 und RANTES zur klinischen Risikostratifizierung von Patienten mit chronischer Hepatitis C
… such as CCR 5 and CX3CR1 and the chemokine RANTES on chronic hepatitis C. The polymorphisms of the CC-chemokinereceptors delta32 (CCR5 delta32), the combined SNPs CX3CR1 V249I and T280M, as well as analysis of the haplotype of the RANTES gene were evaluated and correlated with chemical and …
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Identification of novel chemokine and chemokine-like mechanisms in leukocyte adhesion and atherosclerotic lesion formation
… transcriptional regulator of the CC chemokine RANTES. RANTES is upregulated in mononuclear cells or deposited by activated platelets during inflammation and has been implicated in atherosclerosis and neointimal hyperplasia. Here, the influence of YB-1 on RANTES expression and its contribution …
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Chemokinexpression in kolorektalen Karzinomen : Molekularbiologische und funktionelle Untersuchungen an frisch etablierten Zellkulturen humaner Tumore
… detektierbar (IL-8, GRO-g, SDF-1a, MIP-1ß, RANTES, Ltn). Durch Präinkubation der Tumorzellen mit proinflammatorischen Zytokinen (TNF-a, IFN-g) konnte in zwei von drei Zelllinien chemokinspezifische mRNA (IL-8, MIP-1ß, RANTES, SDF-1a) induziert werden. <br>Als indirekter Proteinnachweis sowie …
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Single Molecule Ligand Binding Studies on CCR5 by Fluorescence Cross-Correlation Spectroscopy
… inhibitors. Recently, four peptides derived from RANTES (Regulated on Activation, Normal T cell Expressed and Secreted), the endogenous ligand of CCR5, were shown to induce different CCR5 signaling pathways and efficiently block viral entry. The peptide analogues are 5P12, which blocks HIV-1 entry …
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Proteomic analysis of TRIF interactome and functional characterisation of novel TRIF interacting proteins
… and TLR4-dependent activation of NF-κB, IFNβ and Rantes promoter activation, respectively. Moreover, downregulation of ADAM15 by esiRNA enhanced poly(I:C) and LPS-induced cytokine/chemokine secretion in the U373-CD14 cell line. This study also demonstrated that all of the three DVLs isoforms …
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Cannabinoid Modulation of Chemotaxis of Macrophages and Macrophage-like Cells
… cells, to the endogenous chemokine RANTES (Regulated upon Activation Normal T-cell Expressed and Secreted) and to Acanthamoeba conditioned medium containing secreted proteases. The partial agonist delta-9-tetrahydrocannabinol (THC), administered in vitro, inhibited the chemotactic …
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Untersuchungen zur Anastomosenheilung am Colon der Wistarratte: Physikalische und zytokinetische Analysen unter Verwendung verschiedener absorbierbarer Nahtmaterialien
… Zytokinmusters (TGF beta, IL-10, RANTES)um die Wundheilung am Colon nach Anastomosierung besser zu verstehen.
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Mechanisms of CCR5 Agonist/Antagonist Inhibition of HIV-1 Entry and In Vitro Selection of Virus Resistant to Maraviroc
… a major mechanism involved in sensitivity to PSC-RANTES. Although downregulation of coreceptor expression from the cell surface was instigated by PSC-RANTES binding, this effect was of short duration and competitive binding modulated viral sensitivity and resistance over time. In addition, in …
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Cytokine patterns in a comparative model of arenavirus infection: Implications for virulence and control of viral replication
… PBL had decreased TNF-alpha, IFN-gamma, and RANTES transcripts. We also examined the ability of a decoy AP-1 thioaptamer, XBY-S2, to alter morbidity, mortality, and cytokine expression during P18 infection of guinea pigs. After two doses of XBY-S2, 50% (p=.024) of treated guinea pigs survived …
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RANDOMISED CONTROLLED TRIALS ON PSYCHOLOGICAL INTERVENTIONS TO PROMOTE MENTAL HEALTH OF COMMUNITY-DWELLING ELDERLY
… decreased and the levels of SDF-1α, RANTES and BDNF maintained, coupled with significant improvements in social connectedness. Conclusion: On top of improving psychometric scores, improvements in biomarkers also provided biological evidence of the interventions. The findings of these …
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Investigations into novel signalling pathways in the response to viral and bacterial infections
… is required for maximal levels of TLR7 mediated RANTES, CXCL10 and IFNβ cytokine secretion but not TNFα production. TLR7 signalling was shown to activate IRF3 and NFκB in murine bone marrow derived macrophages. However, while TLR7 mediated IRF3 activation was TRAM dependent, NFκB activation was …
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L'impatto degli antipsicotici long-acting sui marker della neuroinfiammazione associati alla schizofrenia
… di cito-chemochine, come IL-1β, IL-18, TGF-β1, RANTES, Eotaxina, e la somministrazione di terapia con antipsicotici iniettivi di prima e seconda generazione a rilascio prolungato. Lo studio è stato effettuato su un campione di 18 pazienti con schizofrenia, suddivisi in due gruppi, a cui erano …
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Characterisation of HIV-1 Envelope features of breakthrough infections from the CAPRISA 004 Microbicide Trial
… inhibitors: tenofovir, maraviroc, T20, PSC-RANTES and anti-CD4 antibody clone SK3. In addition, envs for 19 participants were cloned and used to generate pseudoviruses which were evaluated for entry efficiency. Viral isolates were identical or very similar to viruses in circulation in vivo; …
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Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage
… to their respective natural ligands, SDF-1 and RANTES were studied and prototypic R5 and X4 isolates (HIV-1BaL and HIV-1IIIB) were tested for their ability to use these chimeric receptors. The results showed that ligands and virus use different receptor epitopes which, in turn, vary between the …
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The in vitro effects of chemokines on microglia: Implications for multiple sclerosis.
… on MMP2. Interestingly, MCP1, MIP1alpha/beta and RANTES significantly decreased the secretion of uPA by CHME3 cells which may indicate an increase in uPAR expression. These results suggest that chemokine mediated control of MMP activity in the breakdown of the blood brain barrier could allow …
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HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines
… circulating levels of IFN-gamma, MIG and RANTES. IFN-gamma deficient mice demonstrated that this cytokine was necessary for the observed anti tumor effects of therapy with IL-12 plus 4D5. Dual therapy induced tumor necrosis and depletion studies confirmed that NK cells mediated the anti …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… glycoprotein, α1-antitrypsin, PEDF, CC4, ICAM-1, RANTES, clusterin, and cystatin c. We recruited 61 participants (placebo = 31; lithium = 30). The age baseline mean was 40 (±8.35) years and the median CD4+ T-cell count was 498 (IQR: 389 – 651) cells/μL. Biomarker concentrations between groups did …
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