Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"RANKL"”.
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RANKL and Osteoprotegerin Levels in Response to Orthodontic Forces
… activator nuclear factor kappa B ligand (RANKL)—is critical for osteoclastogenesis, and osteoprotegerin (OPG) is a decoy ligand that competitively inhibits RANKL. A higher RANKL/OPG ratio is associated with areas of bone resorption, while a lower ratio occurs in areas of bone deposition …
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Modulation of RANKL and Osteoprotegerin in Adolescents Using Orthodontic Forces
… activator nuclear factor kappa B ligand (RANKL)--is critical for osteoclastogenesis, and osteoprotegerin (OPG) is a decoy ligand that competitively inhibits RANKL. A higher RANKL/OPG ratio is associated with areas of bone resorption, while a lower ratio occurs in areas of bone deposition …
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Statins Regulate IL-1β - Induced RANKL and OPG Production by Human Gingival Fibroblasts
… first one, receptor activator for NF- kB ligand (RANKL) is expressed on hematopoetic stromal cells and periosteal osteoblasts as well as on HGF and PDL cells. RANKL interacts with its corresponding receptor, RANK, on mononucleated osteoclast precursors and induces their activation to multinuclear …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
… developing thymocytes and instead use exogenous RANKL to drive TEC specific maturation, while simultaneously culture the TECs with different Wnt proteins. Our results show that the Wnt antagonist, Sfrp-1, and the Wnt ligand, Wnt-5b, interfere with RANKL-induced maturation as demonstrated by a …
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In vitro Differenzierung von Monozyten der Zelllinine RAW 264.7 zu Osteoklasten, deren Charakterisierung und Wechselwirkung mit Osteoblasten
Das RANKL/RANK/OPG-System spielt eine entscheidende Rolle in der Steuerung der Osteoklastendifferenzierung und -aktivierung durch Osteoblasten/ Knochenmarkbindegewebszellen im Rahmen des Knochenremodelings. Osteoblasten/Knochenmarkbindegewebszellen exprimieren RANKL. Dieses hat im Körper zwei …
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Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System
… CNS dissemination. TM B-ALLs uniquely expressed RANKL, a key regulator of osteoclast differentiation and normal B-cell development. FLT3 inhibition decreased RANKL expression, suggesting at least partial dependence on trFLT3 signaling. RANKL-expressing TM B-ALLs decreased trabecular bone density …
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The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines ©
… of nuclear factor-kB (RANK) and its ligand, RANKL has have been implicated as an important link between breast cancer and metastasis to bone because of their ability to activate intracellular signal cascades leading to altered cancer cell behaviour and bone breakdown. The JAK/STAT5a cell …
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Characterization of the Rank Ligand Positive Giant Cell Found in the Interfacial Membrane
… of total joints. Recent evidence suggests that RANKL, a potent activator of bone reabsorption, is present in the interfacial membrane. Prior research in this laboratory to determine the source of RANKL in the interfacial membrane has revealed the presence of intense areas of RANKL concentration …
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The Effects of a Single Bout of Plyometric Exercise on Anabolic and Catabolic Osteokines in Girls and Adolescents
… and dickkopf 1 (DKK-1)] and the catabolic RANKL pathway, [osteoprotogerin (OPG), receptor activator of nuclear factor kappa-β ligand (RANKL)], as well as the related transforming growth factors (TGF-β1, TGF-β2 and TGF-β3) to an acute bout of plyometric exercise in girls and adolescent …
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Muscular Strength Training Modifies Regulation of Bone Remodeling: Inferences From Serum Biomarkers in Young Women
… activator for nuclear factor kappa-beta ligand (RANKL), osteoprotegerin (OPG), osteocalcin, and N-telopeptide (NTx) were measured in women aged 20 + 1.5 years (mean + SD) who underwent 32 weeks of unilateral isokinetic concentric or eccentric muscular strength training. Changes in serum …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… activator of nuclear factor kappa B (RANKL/RANK) pathway mediate an inflammatory response linked to breast cancer progression. However, the mechanism of how COX-2 and RANKL/RANK regulates the progression of IBC and TNBC, respectively, is unclear. Therefore, we investigated COX-2 and …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… activator of nuclear factor kappa B (RANKL/RANK) pathway mediate an inflammatory response linked to breast cancer progression. However, the mechanism of how COX-2 and RANKL/RANK regulates the progression of IBC and TNBC, respectively, is unclear. Therefore, we investigated COX-2 and …
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Einfluss von GnRH Analoga auf die Metastasierung humaner Mammakarzinomzellen in vitro und in vivo
… erzielt. In HCC-70 Zellen, die sich als RANKL-positiv erwiesen, wurde während der Kokultur mit humanen Osteoblasten eine Regulation des RANKL/OPG-Systems ermittelt, die eine gesteigerte Knochenresorption zur Folge hat. Der Expressionsanstieg von RANKL während der Kokultur konnte durch …
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Physical training, inflammation and bone integrity in elite female rowers
… activator of nuclear factor kappa-B ligand (RANKL)) and energy metabolism (insulin-like growth factor-1 (IGF-1) and leptin), and inflammation (tumor necrosis factor-α (TNF-α)) in elite heavyweight female rowers. Blood samples were drawn from female heavy-weight rowers (n=15) (27.0±0.8y, …
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THE ACUTE EFFECTS OF A SINGLE SESSION OF PLYOMETRIC EXERCISE ON MARKERS OF BONE TURNOVER IN BOYS AND MEN
… receptor activator of nuclear factor kb ligand (RANKL). Boys had higher BAP levels at all time points, with an increase 24 hours post-exercise. No such increase was observed in men. Likewise, NTx levels were higher in boys, with a greater increase over time than in men. OPG and RANKL levels were …
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The in vitro effects of diallyl trisulfide on osteoclast formation and function in RAW 264.7 murine macrophages
… activator nuclear factor-kappa B ligand (RANKL) interacts with the receptor activator nuclear factor-kappa B (RANK), found on osteoclast precursors, precursors of osteoclasts develop into mature osteoclasts. Reactive oxygen species (ROS), nuclear factor kappa B (NF-kappaB) and …
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The Role of IKKβ in Osteoclastogenesis and Inflammatory Osteolysis
… by the Ligand for Receptor Activator of NF-κB: RANKL). Recent research has identified many transcription factors that are activated by RANKL and are important for osteoclast differentiation. One such family of transcription factors is NF-κB. We hypothesized that activators of NF-κB are necessary …
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Studies of the role of nf-κb in controlling osteoclast differentiation and bone loss
… through induction of NF-κB RelB; 2) Similar to RANKL, TNF sequentially activates transcriptional factors NF-κB p50 and p52 followed by c-Fos and then NFATc1 to induce OC differentiation. However, TNF alone nduces very limited OC differentiation. In contrast, it pre-activates OCPs to express cFos …
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Characterising the role of Valosin Containing Protein (VCP) in autophagy and cell differentiation.
… containing VCP mutations are hyper-responsive to RANKL and M-CSF treatment. This suggests that under normal homeostasis VCP plays an important role in regulating the response of osteoclasts to bone microenvironment. However, the mechanisms by which VCP mutations stimulate osteoclast …
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Characterization Of The Skeletal Phenotype In Idua-W392X Knock-In Mice: Bone Metabolism Biomarkers
… of six biomarkers were quantified: collagen (I), RANKL, OPG, TNFα, and CSF-1 isolated from tibiae of wild type, heterozygous, and DUAW392X mice. No significant differences were found between the genotypes for PINP, TRAP5b, and transcription levels of type I collagen. Lower transcriptional levels …
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