Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"RAMP3"”.
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The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
… stimuli. (5) GPR30 directly associates with RAMP3 in-vivo and in-vitro and RAMP3 expression has an impact on GPR30 subcellular localization in the murine heart. (6) GPR30 constitutively form a signalosome with Membrane associated guanylate kinase proteins (MAGUKs) and A Kinase Anchoring …
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Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G Protein-Coupled Receptors
… Class B1 GPCR pharmacology. The effect of RAMP3 expression on GLP1R signalling and desensitisation was measured, with increases in Gαq coupling and intracellular Ca2+ (Ca2+)i mobilisation mediated by GLP1R transiently expressed in HEK293T cells. (Ca2+)I mobilisation was also increased by …
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Molecular and Pharmacological Characterization of the Rat RAMP2B Splice Variant
… receptor (AM2) is also formed by the RAMP3 and CL complex. A partial sequence of a rat RAMP2 splice variant was previously identified in our laboratory. I hypothesized that human tissue expresses RAMP2 splice variants and that a clone of the full-length rat RAMP2 splice variant forms …
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Sites of interaction between calcitonin-family peptides and their receptors
… to receptor interactions. In particular, E74 of RAMP3 has been demonstrated to be crucial for high affinity binding and high potency response of AM at the AM₂ receptor. In addition, a naturally occurring variant of the human CTR lacking the N-terminal 47 amino acids has been characterised in this …
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Investigating The Roles of P63 and P73 Isoforms to Therapeutically Treat P53-Altered Cancers
… IAPP functions through the calcitonin and RAMP3 receptors to limit glucose uptake and reduce glycolysis in the cancer cells resulting in ROS accumulation and apoptosis. Additionally, I have also shown that use of Pramlintide, a synthetic analog of IAPP, mediates tumor regression in …
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Multiplexed Mapping of the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins
… among the three known RAMPs (RAMP1, RAMP2 and RAMP3) and hundreds of GPCRs have never been investigated. To address this gap in knowledge about the GPCR-RAMP interactome, we developed a multiplexed suspension bead array (SBA) immunoassay to detect GPCR-RAMP complexes from detergent-solubilized …