Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"RALA peptide"”.
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Understanding the biological barriers to Jurkat Transfection using non-viral peptides
… of this thesis is to examine the feasibility of RALA peptide to manufacture CAR-T cells. <br/><br/>As primary T-cells are hard to transfect, the key barriers to the transfection of primary T-cells should be explored for further rational designs of transfection agents. The low level of heparin …
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The Development and Characterisation of a Peptide Delivery Platform to Interrogate the Anticancer Effects of Bisphosphonates
The RALA peptide delivery system complexes anionic compounds through electrostatic interactions, to form a nanoparticle with the physiochemical characteristics to cross cellular membranes and escape endosomes; thereby releasing the cargo intracellularly to exert the optimal therapeutic effect. …
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Development of an inhalable nanomedicine for lung cancer
… the stability and functionality of NPs. Herein, RALA peptide that had been successfully incorporated into different formulations, e.g. wound patch and hydrogel, was used to condense plasmid DNA (pEGFP-N1) into NPs, followed by spray drying to produce inhalable powder as a proof of concept of gene …
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The development of novel strategies to modulate epithelial sodium channel (ENaC) activity in chronic obstructive pulmonary disease (COPD)
… CAP inhibitor-based approach utilising natural peptide-based inhibitors, derived from amphibian skin secretions, revealed two lead compounds - QUB- 1916 and QUB-2136. Both peptides were found to exhibit potent low-micromolar or nanomolar inhibitory activity against human airway trypsin-like …