Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"RAG1"”.
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Regulation Of Selection And Central Tolerance By The N-Terminal Region Of Rag1
The RAG1/RAG2 complex rearranges antigen receptor gene segments during VDJ recombination to allow for the generation of a vast array of antigen receptors with specificities against a virtually infinite number of insults. Direct consequences of VDJ recombination include the formation of …
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Exploring the link between RAG1 Cellular Distribution and Components of the CRL4DCAF1 E3 Ligase
… work in the Swanson lab showed the turnover of RAG1 is dependenton DCAF1, the CRL4DCAF1 E3 ubiquitin ligase, and the 26S proteasome. RAG1 sequestration in nucleoli and nuclear puncta have been implicated in regulating its activity. RAG1 nucleolar egress and puncta formation are dependent on the …
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Molecular Approaches to Facilitate Marker-Assisted Selection for Soybean Aphid Resistance in Soybean
… study was to test the associated effects of Rag1 on several important agronomic traits including yield in two elite Midwest adapted soybean backgrounds. This study was done because sometimes the introgression of resistance genes from nonadapted sources can carry undesirable genes through …
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Generation and analysis of transgenetic mice expressing catalytically inactive recombination activating gene-1
… encoded by the recombination activating genes (RAG1 and RAG2) are lymphoid cell-specific endonucleases that initiate V(D)J recombination; the mechanism by which the exons that encode the variable portion of both B and T cell receptors are assembled somatically from several variable (V), joining …
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Soybean Resistance and Defense Responses Against Aphis Glycines
… gene in Dowling and Jackson, tentatively named Rag1 and Rag (Jackson) respectively, were mapped on soybean genetic linkage group M by simple sequence repeat (SSR) molecular markers. Rag1 was flanked by Satt435 and Satt463 4.0 cM and 8.0 cM from Rag1, respectively, in the integrated map from …
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Investigations into the Biological Roles of the E3 ligase Ariadne 2/TRIAD1
… and can fully reconstitute lethally irradiated Rag1-/- recipient mice. These Rag1-/-Arih2-/- chimeras recapitulate the lymphoproliferative disorder observed in the mixed background Arih2-/- mice. Further analysis show Rag1-/-Arih2-/- chimeras display increased number of lymphocytes, …
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Molecular Phylogenetics of Perciform Fishes Using the Nuclear Recombination Activating Gene 1
… copy, nuclear recombination activating gene 1 (RAG1). Results of these tests reject the monophyly of the Perciformes and of its largest suborder, the Percoidei. However, this study does support some previous relationships at the suborder and family level for these groups and also presents novel …
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Genetic improvement of aphid resistance, protein, and elemental composition in soybean
… pest can be controlled by the resistance genes Rag1 and Rag2, which have been introgressed into Midwestern adapted soybean lines. In previous studies, the Rag2 resistance allele was shown to be associated with a seed yield reduction. The objective of this study was to confirm the reduction in …
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Evaluation of soybean aphid resistance, yield qtl confirmation, and genetic gain in soybean
… are four known soybean aphid resistance genes (Rag1 through Rag4) and a fifth gene, Rag5, which was identified at the Rag2 locus. Soybean aphid biotypes have also been identified that can overcome Rag1 and Rag2. Soybean aphid resistance was examined in the greenhouse in a collection of F2 …
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Soybean aphid intra-biotype variability based on colonization of specific soybean genotypes, resistance responses of soybean genotypes to pathogen infection after the application of chemical elicitors, and resistance to charcoal rot identified in ancestral soybean germplasm
… 3 isolate on the soybean genotypes Dowling (Rag1), LD05-16611 (Rag1), LD11-4576a (Rag1), and PI 567598B (rag1b and rag3). The Moline isolate was a variant of aphid biotype 3, which is the first report showing that soybean aphid isolates that classified as the same biotype, based on virulence …
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Modeling dengue viral infection, insect transmission and multiplex PCR in humanized mice
… natural dengue pathogenesis and immune response. RAG1-/- γc-/- or RAG2-/- γc-/- mice are immune-compromised and do not reject foreign grafts. This allows engraftment of human hematopoietic stem cells via intrahepatic injection into newborn mice, forming the RAG-hu mouse model. Bone marrow, liver, …
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Genetic diversity and fungicide sensitivity of Rhizoctonia solani associated with soybean seedling disease
… combinations of aphid resistance genes, Rag1, Rag2, and Rag3 to four soybean aphid biotypes, the Rag1/2/3 pyramid was found to be the most effective.
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Modulation of the NFAT signaling pathway by protein kinase B (PKB) ; a perspective study in the context of thymocyte development and T cell function
… development by PKB is due to the expression of RAG1 and subsequent TCRb chain expression. CsA treatment of neonatal thymic lobes from dCam mice restores normal thymocyte development, indicating involvement of NFATs in the severe block in dCam thymocyte development.Confocal studies clearly …
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The phylogeography of Cheracebus species located in the Rio Negro basin and its implications for our understanding of the historical biogeography of Amazonia
… Cytochrome B, D-Loop) and one nuclear marker (RAG1). We constructed haplotype networks and preferred phylogenetic analysis to analyse their genetic differences.Our results show genetic differences for these markers between the three species of titi monkey but little variation between the …
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Role of AID and microRNA-155 in c-myc-IgH Translocations
… by recombinase activating genes 1 and 2 (RAG1/2) during antigen receptor assembly in pre- B cells, suggesting that these translocations might be the result of aberrant V(D)J recombination. However, in mature B cells undergoing AID dependent somatic hypermutation (SHM), duplications or …
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Innate memory to bacterial infection
… higher counts of P. aeruginosa. Experiments in RAG1 knockout (Ko) mice lacking T and B cells, which received immunisation at different time points and infection on day 0 post immunisation led to an increased level of the proinflammatory cytokine IL-22. These results led to the conclusion that …
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On the role of treml6 in B-1a B cell development And ICOS co-stimulation in adaptive immune responses against M. tuberculosis
… die Transplantation von adultem treml6-/- KM in Rag1-/- Mäuse in einer normalen Rekonstitution aller B Zellpopulationen des Rezipienten. Transplantierten wir jedoch aus treml6-/- fetalen Leberzellen generierte pre-B I Zellen, so zeigte sich, dass sie im Vergleich zu WT pre-B I B Zellen, eine …
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QTL discovery for Japanese beetle resistance in aphid-resistant germplasm, stacking aphid-resistant genes, and metabolite profiling studies in soybean
… mapping population gave an opportunity to stack <Rag1> and <rag3> aphid-resistant genes. Pyramiding multiple resistance genes, particularly with different modes of action, has great potential to provide durable resistance. This dissertation also reports MSU soybean breeding program's research on …
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Developing a Novel, Safe, and Effective Platform for Generating Flavivirus Vaccines
… studies. However, vaccination studies in Rag1 KO, Tcra KO, and muMt- mice demonstrate the critical role of T-cell responses in developing immunity post-vaccination. In summary, ARPV/ZIKV is a promising vaccine candidate that induces robust adaptive immune responses, and this success is a …
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Exploring antiviral effector cells in vaccinia virus-infected tissues
… alone to clear labial VACV infection as *Rag1-/-* mice (which lack T and B cells, but retain ILCs) have prolonged viral replication which can be reduced by adoptively transferred T cells. Together, these findings illustrate the complexities of immune-cell-mediated interactions and …
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