Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"RAG-1"”.
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Studies of the structure and function of the RAG-1 and RAG-2 genes
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1993.
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Die Rolle von Immunzellen bei der primär genetisch-vermittelten Demyelinisierung in einem Mausmodell für die Charcot-Marie-Tooth-Neuropathie, Typ 1X
… und Fibroblasten beobachtet. 4. In Cx32def/RAG-1-/- Doppelmutanten, die zusätzlich zu der Myelinmutation auch keine reifen Lymphozyten beinhalten, ist eine signifikant geringere Hochregulation der Anzahl von endoneuralen Makrophagen nachweisbar, ebenso eine wesentliche Abmilderung der …
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Pathogenic impact of immune-related cells in Batten disease
… crossbred PptP/- mutants with mice deficient in Rag-1, which lack T- and B-lymphocytes. Disease progression was significantly delayed in immune deficient PptP/ /Rag-1-/- mice, which displayed ameliorated neuroinflammation and neuron loss. We also crossed our Infantile and Juvenile NCL mouse …
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Developing a diagnostic assay for Pneumocystis jirovecii pneumonia and investigating the interaction of Pneumocystis murina and respiratory syncytial virus during co-infection in mice
… viral pneumonia. Wild-type and immunocompromised RAG-1-deficient mice were infected with P. murina followed by RSV and the disease parameters were investigated. RT qPCR analysis demonstrated that P. murina infection reduced RSV burden in coinfected mice compared to RSV-only mice. Pro-inflammatory …
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Investigations on the role of SLP-65 and other B cell signaling proteins in human leukemia
… combined with proliferation capacity and active RAG 1/2 enzymes may be the primary cause of pre-B ALL.
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Elucidating cryptic diversity in East African frogs : the case of Arthroleptis francei Loveridge, 1953
… were based on sequence data across one nuclear (rag-1, 629bp) and two mitochondrial (12S and 16S, 352bp and 455bp, respectively) genes, and suggest the presence of several cryptic taxa linked to mountain clusters. The Bayesian analysis yielded putative species within the mitochondrial gene (16S). …
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A Phylogenetic History of the Tenerife Skink Chalcides viridanus: A multi-locus Coalescent Approach
… undertaken, using more informative mtDNA gene fragments (Cyt-b & ND1 & 2, totalling 1566bp) as well as the sequencing of 5 nuclear loci (PRLR-555bp, Rag-1-761bp, RELN-583bp, EXPH-796bp and SELT-414bp). These sequences were combined with the latest Bayesian methods to estimate divergence times, …
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Phylogenetics and Phylogeography of Moray Eels (Muraenidae)
… with widespread taxonomic and geographic coverage, including 44 species representing two subfamilies, eight genera, and all tropical ocean basins. Phylogenetic relationships among these taxa are estimated from portions of mitochondrial loci <italic>cytochrome b</italic> and <italic>cytochrome …
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DNA Persistence and Preservation Following Environmental Insult
… points. Rabbit recombination activating gene (RAG 1) was aligned to identify conserved regions in pig, rabbit and human. Primers were designed and optimised to create a 4-plex PCR multiplex that can amplify 70 bp, 194 bp, 305 bp and 384 bp in three species. The 4-plex multiplex was found to …
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Regulation of T cell effector functions in the intestinal mucosa
… il-18r-/- CD45RBhighCD4+ T cells into rag-1-/- mice. The number of IFN-γ producing CD4+ T cells recovered from the colitic colon LP were significantly reduced compared to their wild type counterparts and il-18r-/- CD4+ T cells in the setting of colitis failed to produce cytokines in …
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Immunodulation of inflammation in a murine pnemococcal sepsis model
… C57BL/6, BALB/c, CBA/CaHN-Btkxid'/J, A/J, Rag-1 KO, IL-10 KO , C3H/HeN and C3H/HeJ mice were inoculated intravenously with a lethal dose of 106 cfu of S. pneumoniae serotype 2 48 hours after treatment with five doses of 10ug highly purified LPS or vehicle (PBS) at 12 hours interval. Another …