Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"RAD51D"”.
-
Regulation of Rad51D In Homologous Recombination Dna Repair by Alternative Splicing and Ubiquitin Modification
… modification.</p> <p>The initial focus was on RAD51D, a central component of HR previously demonstrated to repair DNA damage as well as maintain chromosome and telomere stability. In the first study, mouse Rad51d alternative transcript products were found to make specific interactions with …
-
The behavior of RAD51D and XRCC2 in response to drug induced DNA damage and a continuing study of the fly RAD51 paralogs
… followed two Drosophila Rad51 paralogs, dmRad51D and dmXRRC2, and using constructs tagged with GFP, found that they entered the nucleus in response to drug induced DNA damage. Approximately one hour after the induction of DNA damage via bleomycin, dmRad51D and dmXRCC2 entered the nucleus of …
-
RNA and protein expression patterns of the Drosophila XRCC2 Homolog
… to have five recA like proteins: Rad51B, Rad51C, Rad51D, XRCC2 and XRCC3. In Drosophila Rad51/SpnA, XRCC3/SpnB, and Rad51 C/SpnD participate in homologous recombination repair. The function of DmRad51 D and DmXRCC2 are unknown. The goal of this project was to elucidate the function ofXRCC2 in …
-
The Rad51 family of proteins: Interactions, vitamin D, and implications in head and neck cancer
… known as the Rad51 paralogs, Rad51B, Rad51C, Rad51D, XRCC2, and XRCC3, whose loss of function in cell lines leads to high chromosomal instability. Previous studies have shown Rad51C participate in two paralog protein complexes, one containing Rad51B, Rad51C, Rad51D and XRCC2 (BCDX2) and the …
-
Role of XRCC3 in Acquisition and Maintenance of Invasiveness through Extracellular Matrix in Breast Cancer Progression
… or RAD51 cofactors (namely RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3) which interact with each other to form complexes (BCDX2, BC, DX2 and CX3) that collaboratively assist RAD51 in homologous recombinational repair (HRR) of DNA double-strand breaks. To see if these interactions are important …
-
Assessing the impact of non-coding mutations on breast cancer risk predisposition genes
… However, 4 such variants in BRCA1, FANCG, RAD51D and MRE11A;ANKRD49 were shown to potentially have an effect on gene expression. These promoter variants are candidates for further investigating their role in breast cancer.<br/><br/>Methods for calculating DDRD scores from microarray data …
-
Interactions of human and drosophila Rad 51 paralogs
… Rad51 gene, and its four paralogs Spn D, Spn B, Rad51D, XRCC2 (the last 2 identified by sequence homology), and human hsRad51D and hsXRCC2, were cloned into Invitrogen's TOPO protein expression vector. When induced with IPTG, the resulting fusion proteins contains either aN-terminal Xpress TM …
-
Examination of molecular genetic factors involved in sensitivity to breast cancer following radiation exposure
… double-strand break repair protein, Rad51D. The emerging interrelations between DNA repair and telomere maintenance also prompted us to evaluate Rad51D's role in telomere function. The final aspect of this research involved examination of how DNA repair related proteins are linked to …
-
Genetic Testing Uptake and Yield in Patients with Male Breast Cancer
… <em>PTEN</em>, <em>RAD51C</em>, <em>RAD51D</em>, <em>STK11</em>, and <em>TP53</em>, and compare genetic testing uptake and yield of gPV in the clinically actionable genes for MBC: <em>BRCA1</em>, <em>BRCA2</em>, and <em>PALB2</em>, by age at diagnosis, race, and ethnicity, in a MBC …
-
Analysis and confirmation of the results of a yeast two-hybrid screen carried out to identify proteins that interact with drosophila XRCC2
… such as XRCC2, XRCC3, RAD51B, RAD51C, and RAD51D, performs the critical initiating steps of homologous pairing and strand transfer. The proteins encoded by the familial breast cancer genes, brcal and brca2, also play an important role in HRR.</p> <p>My project is concerned with studying …
-
Identification of determinants of sensitivity to duocarmycin analogues: A class of potent anti-cancer drugs
… in human colorectal cancer cell line and RAD51D-/- in CHO hamster cell line) showed hypersensitivity to treatment with duocarmycin analogues. The findings suggested that DNA alkylation is the main MOA and homologous recombination repair proteins are potential determinants of sensitivity to …
-
Rare Genetic Variants and Cancer Susceptibility
… in ATM, BARD1, BRCA1, BRCA2, CHEK2, RAD51C, RAD51D, PALB2 and TP53. However, these variants together explain less than half the familial relative risk of breast cancer. Similarly for other cancers, GWAS have identified many susceptibility loci and rare variants have been identified in a few …
-
Homology-Directed Repair of Dna Lesions Generated by the Mismatch Repair Dependent Processing of Cytotoxic Guanine Adducts
<p>Methylating agents are widely used in chemotherapy and kill cancer cells by causing DNA damage. The O6-methylating anticancer drugs procarbazine, dacarbazine, and temozolomide generate O6-MeG adducts, while a thiopurine antimetabolite 6-thioguanine (6-thioG) generates S6-MeG DNA adducts. Instead …