Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"RAD51C"”.
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Etablierung eines neuen Rekombinations-Meßsystems und Nachweis der Störung homologer Rekombination in Atm- und Rad51C-defizienten Säugerzell-Mutanten
… V79B und deren mutierte Variante CL-V4B (Rad51C(-/-) (Godthelp et al., 2002)) konnte die vermutete Störung der HR in den Rad51C-defizienten CL-V4B-Zellen (Masson et al., 2001; Takata et al., 2001; French et al., 2002; Godthelp et al., 2002) eindeutig nachgewiesen werden: Im Vergleich zur …
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The Rad51 family of proteins: Interactions, vitamin D, and implications in head and neck cancer
… to Rad51 known as the Rad51 paralogs, Rad51B, Rad51C, Rad51D, XRCC2, and XRCC3, whose loss of function in cell lines leads to high chromosomal instability. Previous studies have shown Rad51C participate in two paralog protein complexes, one containing Rad51B, Rad51C, Rad51D and XRCC2 (BCDX2) …
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Role of XRCC3 in Acquisition and Maintenance of Invasiveness through Extracellular Matrix in Breast Cancer Progression
… proteins or RAD51 cofactors (namely RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3) which interact with each other to form complexes (BCDX2, BC, DX2 and CX3) that collaboratively assist RAD51 in homologous recombinational repair (HRR) of DNA double-strand breaks. To see if these interactions are …
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Regulation of Rad51D In Homologous Recombination Dna Repair by Alternative Splicing and Ubiquitin Modification
… were found to make specific interactions with RAD51C and XRCC2. In addition, Rad51d alternative transcripts exhibited tissue-specific expression patterns in both mouse and human cells. This study suggested that RAD51D splice variants have the ability to sequester HR components into inactive …
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Γενετική ανάλυση στον κληρονομικό καρκίνο του μαστού
… του μετρίου διεισδυτικότητας γονιδίου RAD51C σε ελληνικές οικογένειες. Η ανάλυση αυτή πραγματοποιήθηκε σε 87 ασθενείς όμως δεν ανιχνεύθηκε κάποια παθογόνος μετάλλαξη σε κάποιον ασθενή. Επιπρόσθετα, πραγματοποιήθηκε η ανίχνευση μεγάλων γονιδιακών αναδιατάξεων στα γονίδια BRCA1 και BRCA2 …
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RNA and protein expression patterns of the Drosophila XRCC2 Homolog
… thought to have five recA like proteins: Rad51B, Rad51C, Rad51D, XRCC2 and XRCC3. In Drosophila Rad51/SpnA, XRCC3/SpnB, and Rad51 C/SpnD participate in homologous recombination repair. The function of DmRad51 D and DmXRCC2 are unknown. The goal of this project was to elucidate the function ofXRCC2 …
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Genetic Testing Uptake and Yield in Patients with Male Breast Cancer
… <em>NF1</em>, <em>PALB2</em>, <em>PTEN</em>, <em>RAD51C</em>, <em>RAD51D</em>, <em>STK11</em>, and <em>TP53</em>, and compare genetic testing uptake and yield of gPV in the clinically actionable genes for MBC: <em>BRCA1</em>, <em>BRCA2</em>, and <em>PALB2</em>, by age at diagnosis, race, and …
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Analysis and confirmation of the results of a yeast two-hybrid screen carried out to identify proteins that interact with drosophila XRCC2
… of other proteins such as XRCC2, XRCC3, RAD51B, RAD51C, and RAD51D, performs the critical initiating steps of homologous pairing and strand transfer. The proteins encoded by the familial breast cancer genes, brcal and brca2, also play an important role in HRR.</p> <p>My project is concerned with …
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Functional analyses of hTel2 and TRF2 deltaB: Insights Into the Role of a New DNA Damage Pathway and Homologous Recombination in Mammalian Telomere Function
… the Mrell complex, and XRCC3, a component of the RAD51C/XRCC3 Holliday junction (HJ) resolvase, suggesting the involvement of homologous recombation (HR) in the deletions. Consistent with a role for HR, TRF2AB induced the formation of t-loop-sized telomeric circles. These telomeric circles were …
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Rare Genetic Variants and Cancer Susceptibility
… variants in ATM, BARD1, BRCA1, BRCA2, CHEK2, RAD51C, RAD51D, PALB2 and TP53. However, these variants together explain less than half the familial relative risk of breast cancer. Similarly for other cancers, GWAS have identified many susceptibility loci and rare variants have been identified in …