Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"RAD51 Recombinase"”.
-
Mechanism of regulation of human RAD51 recombinase through post translational modifications & mediator proteins
RAD51 protein plays an important role in homologous genetic recombination (HR), an essential DNA metabolic process used by cells to faithfully repair the most deleterious forms of DNA damage and maintain genomic integrity. RAD51 along with its bacterial counterpart RecA, bacteriophage UvsX and …
-
Mechanisms of human RAD51 regulation by RAD52 and BRCA2
The RAD51 recombinase assembles as helical nucleoprotein filaments on single-stranded (ss)DNA substrates to mediate homologous DNA recombination (HR) and replication fork protection, processes vital in human cells for the maintenance of genome stability. RAD51 assembly is controlled by two key …
-
Identification of MMS22 as a regulator of DNA repair
… are required for the efficient loading of the RAD51 recombinase onto resected DNA ends and for efficient HR. These data indicate that MMS22L and TONSL are novel regulators of genome stability that enable efficient HR.
-
RAD51-MEDIATED ABASIC SITES PROTECTION PREVENTS REPLICATION FORK COLLAPSE.
… for the homologous recombination (HR) protein RAD51 in AP site protection and repair during genomic DNA replication. Our findings provide direct evidence that unrepaired AP sites generate discontinuous ssDNA stretches at replication forks onto which RAD51 binds preventing MRE11-RAD50 …