Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"RAD21"”.
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Localization studies of sister-chromatid cohesion proteins MEI-S332 and RAD21 in Drosophila
… cohesion proteins in Drosophila, MEI-S332 and RAD21. MEI-S332 localizes specifically to the centromere from prometaphase to the metaphase-anaphase transition in mitosis, and from prometaphase I to the metaphase II-anaphase II transition in meiosis. We find that the termini of MEI-S332 are …
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Chromosome dynamics during cell divisions in Drosophila melanogaster: The role of Rad21 in meiotic cohesion and dynamic analysis of the condensin subunit CapG in early embryonic mitotic divisions
… a possible cohesive role for the mitotic subunit Rad21 during female meiosis. Furthermore, a potential redundancy during oogenesis between Rad21 and another candidate cohesin subunit, C(2)M, was analyzed. Forced proteolysis of Rad21 during oogenesis resulted in delocalization of the canonical …
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Analyse des meiotischen Cohesinkomplexes in Drosophila melanogaster-Weibchen
… SMC3 und den zwei nicht-SMC Untereinheiten Scc1/Rad21/Mcd1 und Scc3/SA. In Metazoen wird der Großteil der Cohesinmoleküle während der Prophase vom Chromatin entfernt, während ein kleiner Teil am zentromerischen Chromatin verbleibt und erst beim Metaphase-Anaphase-Übergang durch eine …
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Analysis of the S. pombe sister chromatid cohesin subunit in response to DNA damage agents during mitosis.
… of this study are two homologous cohesin genes rad21+ and rec8+ expressed exclusively in either mitosis or meiosis respectively of the fission yeast Schizosaccharomyces pombe. All eukaryotes have two copies of these genes both analogously expressed and functionally similar, but undergoing life …
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Novel Protein-protein Interactions Regulate The Proteolytic Activity Of The Pro- Apoptotic Serine Protease, Omi/htra2
… system and Omi as the "bait" protein. Human Rad21 protein was isolated as a specific novel interactor of Omi. Human Rad21 interacted with the PDZ domain of Omi, the part of the protein known to be involved in protein-protein interactions. Human Rad21 is a nuclear protein that plays a role in …
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Regulatory architecture of the Pax6 locus
… a key role for CTCF and cohesin (subunit Rad21) in chromatin organisation and long distance regulatory interactions. ChIP-chip for CTCF/Rad21 across the Pax6 locus identified numerous sites within the gene and at distal regulatory locations. The majority of these sites are cell type …
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A Mechanistic Evaluation of the Role of Aneuploidy During Oncogenesis
… mechanism of one chr8 gain-driver gene, RAD21, in mitigating EWS-FLI1-induced replication stress and promoting oncogenesis. We find that the overexpression of RAD21 facilitates the resolution of transcription-replication conflicts in EWS-FLI1 expressing cells. This is achieved partially …
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Leveraging Genomic Information for Safer Gene Therapy
… sequence. Our findings showed that CTCF and RAD21 occupancy as the major but not the sole contributor for insulator activity. We also identified the influence of sequence specific features such as downstream motif to regulate the insulator function. Furthermore, we discovered that insulators …
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Simultaneous Targeting of CDK4/6 and BETs is Independent of RB Status in Osteosarcoma
… in replication stress (RS) pathways (MYC, RAD21) and cell cycle regulators (CDKN2A, CDK4/6), pointing to CDK4/6 inhibitors (CDK4/6i), like palbociclib and abemaciclib, as promising therapeutic strategies. However, monotherapy often fails, highlighting the need for effective combination …
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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
… transcription factors, including pSTAT1, RUNX1, RAD21, STAT3, ETO2, FLI1, GATA2, LYL1, LDB1 and PU.1. We showed NFIX and PU.1 together target genes regulating hematopoietic cell adhesion, cell death and differentiation in hematopoietic cells. Our data support a model in which NFIX collaborates …