Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"RAB5A"”.
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MECHANO-CHEMICAL FEEDBACK VIA CONTACT PERCOLATION REGULATES PHASE TRANSITION AND TRANSCRIPTIONAL STATE IN HETEROGENEOUS BREAST CANCER
… tumor invasion. We recently demonstrated that RAB5A, an endocytic small GTPase, induces tissue fluidification, promotes BC progression, and triggers an inflammatory gene response via cGAS/STING pathway and the acquisition of malignant traits. While prior studies used genetically homogeneous …
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Cryo-EM structural exploration of human VPS34 complexes and their activation by RAB GTPases and NRBF2
… by RAB GTPases RAB1A (for complex I) and RAB5A (for complex II), but the mechanistic details of how this specificity is achieved have remained elusive due to a lack of high-resolution structural data for human VPS34 complexes. In this work, I used single particle cryo-EM to determine the …
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A New Approach To Identifying Effectors and Regulators of Small GTPases
… the Rab GTPases Rab2A (ARFGEF3/BIG3, STAMBPL1), Rab5A (OSBPL9, TBCK), Rab9A (HPS3, NDE1), and Rab11A/B (ALS2). Furthermore, numerous novel interactors were identified for Rab1A and Rab1B, two mammalian paralogues of the yeast protein Ypt1 that are known to be key regulators in ER to Golgi …
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Identification of genes involved in macrophage activation and effector functions against intracellular pathogens
… generated the hypothesis that PKCδ may promote Rab5a activation, which together with localized release of superoxide into the phagosome and activation of C/EBPβ by PKCδ, resulted in the confinement of the L. monocytogenes within the phagosome. Alternatively, PKCδ may act in a separate pathway …