Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"RA1190 Toxicology. Poisions"”.
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Integration of Data Quality, Kinetics and Mechanistic Modelling into Toxicological Assessment of Cosmetic Ingredients
… conclusions being more usable/acceptable within toxicology. Within this thesis (and associated publications) novel methodologies on how to assess and employ statistical data quality and how to screen for potential liver toxicants have been described. Furthermore computational tools, such as …
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In Silico Classification of Industrial Chemicals Associated with Acute Aquatic Toxic Action Utilising Molecular Initiating Events
… an in silico classification scheme for aquatic toxicology to enable grouping according to relevant mechanism of action. Over 6,200 publicly available toxicity data for nearly 5,000 chemicals and 10 aquatic species were collated and curated to form the basis of the analysis. In addition, …
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THE INTEGRATED USE OF PHYSICOCHEMICAL AND IN VITRO DATA FOR PREDICTING CHEMICAL TOXICITY
The general aim of this PhD project was to investigate the integrated use of physicochemical and in vitro data for predicting the toxicological hazard of chemicals in animals. This was achieved in two stages: firstly, by developing two types of model for acute dermal and ocular toxicity - …
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Development of in silico models to support repeat dose safety assessment of cosmetic ingredients to humans
Cosmetic products are used daily on a global scale. Therefore, it is necessary to ensure that these products, and their ingredients, do not cause any adverse human health effects under normal usage; to ensure this, risk assessment must be performed. Traditionally, risk assessments are performed in …
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Quantitative structure-activity relationships of comparative toxicity to aquatic organisms.
Quantitative Structure-Activity relationship (QSAR) attempt statistically to relate the physico-chemical properties of a molecule to its biological activity. A QSAR analysis was performed on the toxicities of up to 75 organic chemicals to two aquatic species, Photobacterium phospherum (known as the …
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The Cytotoxic Effects of Malondialdehyde on Human Lung Fibroblast Cells
Malondialdehyde (MDA) is a mutagenic and carcinogenic product of lipid peroxidation which has also been found at elevated levels in smokers. MDA reacts with nucleic acid bases to form pyrimidopurinone DNA adducts, of which 3-(2-deoxy-β-D-erythro-pentofuranosyl)pyrimidol[1,2-α]purin-10(3H)-one …
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A systems toxicology framework for improving the identification of paracetamol overdose
… sub-optimality. Within this thesis, a systems toxicology approach is taken in an attempt to provide further insight into the APAP overdose problem, and propose potential improvements to the current treatment framework. In Chapter 2, a proof-of-concept pre-clinical …
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QSAR studies of surfactant toxicity to Daphnia magna.
The inherent nature of surfactants to aggregate at surfaces makes measurement of log P (octanoll water partition coefficient) for these substances extremely difficult. It is possible, however, to calculate a log P descriptor based on the method described by Hansch and Leo (1979). Work presented in …
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Development of in silico models for the prediction of toxicity incorporating ADME information
Drug discovery is a process that requires a significant investment in both time and resources. Although recent developments have reduced the number of drugs failing at the later stages of development due to poor pharmacokinetic and/or toxicokinetic profiles, late stage attrition of drug candidates …