Global ETD Search
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Showing 1 to 3 of 3 for “"R9AP"”.
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Molecular Dissection of Multifunctional Proteins in Rod Outer Segments
… of two multifunctional outer segment proteins, R9AP and rhodopsin, and also reassesses the localization of Glut1, a third protein formerly believed to reside in the outer segment. All three experimental lines relied on in vivo expression of novel protein constructs in vertebrate rods using …
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THE ROLE OF R7 REGULATORS OF G PROTEIN SIGNALING IN THE RETINA
… of the transducin GAP complex (RGS9-1/Gβ5L/R9AP). The Gβ5L isoform is also only expressed in retinal photoreceptors and acts by stabilizing the GAP complex. The Gβ5S isoform differs from Gβ5L by the absence of exon 1 due to alternative splicing and is expressed in many other retinal cells. …
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RATE-LIMITING STEP OF CONE PHOTOTRANSDUCTION RECOVERY AND OGUCHI DISEASE MECHANISMS
… protein (GAP) complex comprised of RGS9-1/Gβ5-L/R9AP. Mutations in human genes involved in these reactions cause various visual defects. Cone, by and large, uses the same set of genes for pigment and transducin deactivations but it has lower sensitivity and faster kinetics than rod and is …