Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"R6/2 mouse"”.
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The Role of Trophic Factors and Other Drugs in the Treatment of Huntington's Disease in R6/2 Mouse Model
… JNK. We hypothesized that the treatment of the R6/2 transgenic mouse model with neurotrophic peptides, Colivelin and analogue dPEG-Colivelin, Sulforaphane, a compound that reduces oxidative stress, and Ceftriaxone, a GLT-1 upregulator, would attenuate motor behavioral abnormalities and …
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β-cell dysfunction in Huntington's disease
… neuronal disease. Upon characterization of the R6/2 mouse model we found that mutant huntingtin renders β-cells replication-deficient. This results in a reduced β-cell mass in R6/2 compared to WT mice. In addition, islet insulin content is reduced and a dramatic degranulation of β-cells is …
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Stem cell transplantation in mouse models for Huntington's disease
… the experiments of stem cell transplantation in mouse models for Huntington´s disease. The most common rodent model for HD is the QA-lesion model, where quinolinic acid is injected unilaterally into the striatum of adult rats. We adapted this method for use in mice and transplanted syngeneic …