Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"R6/2"”.
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The mGluR2/3 Agonist LY397268 Improves Morphometric and Behavioral Outcomes in R6/2 Huntington's Disease Mice
… LY379268 had a number of beneficial effects in R6/2 mice, including an 11% improvement in lifespan and various locomotor parameters. The drug showed improvement in open field measurements of overall activity, speed, acceleration, and endurance. Histological and tissue analysis revealed a reduced …
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The Role of Trophic Factors and Other Drugs in the Treatment of Huntington's Disease in R6/2 Mouse Model
… JNK. We hypothesized that the treatment of the R6/2 transgenic mouse model with neurotrophic peptides, Colivelin and analogue dPEG-Colivelin, Sulforaphane, a compound that reduces oxidative stress, and Ceftriaxone, a GLT-1 upregulator, would attenuate motor behavioral abnormalities and …
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Calcium Channel Dysfunction in Huntington’s Disease
… were conducted using the transgenic R6/2 HD mouse model, which, has a CAG expansion of approximately 144 repeats and displays progressive motor and behavioral dysfunction similar to those found in HD patients. The patch clamp method was used to record whole-cell HVA Ca<sup>2+</sup> …
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Beyond the basal ganglia
… found that weight loss in both HD patients and R6/2 mice (a transgenic model of HD) is not caused by changes in caloric intake or locomotor activity. Metabolism was, however, increased in R6/2 mice and this may be the cause of weight loss. Interestingly, weight loss increases with higher CAG …
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Veränderungen der cholinergen, dopaminergen und noradrenergen Transmitterfreisetzung und -wiederaufnahme in einem transgenen Mausmodell für Chorea Huntington
… Veränderung ihrer Freisetzung in der transgenen R6/2-Maus ist eines der Themen der vorliegenden Arbeit. <br> <br>Ein Ziel dieser Arbeit war die Beschreibung der Veränderungen des cholinergen Systems im Striatum der R6/2-Maus. Wir betrachteten dabei die 3 Teilbereiche: Synthese, Freisetzung und …
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β-cell dysfunction in Huntington's disease
… neuronal disease. Upon characterization of the R6/2 mouse model we found that mutant huntingtin renders β-cells replication-deficient. This results in a reduced β-cell mass in R6/2 compared to WT mice. In addition, islet insulin content is reduced and a dramatic degranulation of β-cells is …
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Neurochemical Measurements in Rodents that Model Huntingtion's Disease and Oxidative Stress
… that model HD. Genetic HD model mice and rats (R6/1 mice, R/2 mice, and HDtg rats) showed an age-dependent decrease in dopamine release in the dorsolateral caudate putamen. A similar decrease is not seen in 3-nitropropionic (3NP)-treated rats. In the case of R6/2 mice, stimulation at increasing …
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Cell-Type Specific Translational Profiling in Huntington's Disease Mouse Models
… striatopallidal and striatonigral MSNs in the R6-2 and YAC128 HD mouse models at pre- and post-symptomatic time points using the BACTRAP technique (Heiman et al, 2008). We re-characterized the behavioral phenotype of the HD model mice on the D1 and D2 TRAP backgrounds and found many changes in …
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The sHsp expression signature in the brain and modulation in models of chronic neurodegeneration
… in<br/>two distinct models of intracellular (R6/2) and extracellular (ME7) proteinopathies. These<br/>models recapitulate key features of Huntington’s and prion disease, respectively.<br/><br/>Analysis of the sHsps in the R6/2 Huntington’s disease (HD) mouse model showed a …
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Preclinical Evaluation of Matrix Metalloproteinase Inhibitors and Protein Kinase C Activators in Cell and Mouse Models of Huntington’s Disease
… increased the average life span in HD R6/2 treated mice.</p>
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Identification of cellular signaling events dysregulated in Huntington’s disease.
… a previously designed array with 298 peptides b) R6/2 HD mouse model across key developmental time points using customized arrays with 1268 peptides. In an effort to investigate disease-associated changes in signal transduction activity, global patterns of kinase activity (kinome analysis) were …
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Regulation of Transglutaminase by 5-HT2A Receptor Signaling and Calmodulin
… was injected into the striatum of HD transgenic R6/2 mice and littermate control mice. The HD mice with CaM-fragment expression had significantly reduced body weight loss and improved motor function compare to HD control mice. Without affecting the activity of CaM-dependent enzymes such as …