Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"R-loops"”.
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Mechanism of transcription termination: Role of chromatin and R-loops
… por los cuales los híbridos de ARN:ADN (R-loops) y la dinámica de la cromatina influyen en la terminación de la transcripción en la levadura Saccharomyces cerevisiae. Históricamente asociados con la inestabilidad genómica, los R-loops desempeñan un papel como reguladores de la terminación …
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p53 acts to prevent the formation of pathological R-loops during epigenetic stress
… very few studies which compare them directly. R-loops are three stranded nucleic acid structures that form during transcription and have known physiological roles in influencing their surrounding epigenetic environment. Despite these physiological roles, R-loops are also implemented in inducing …
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Papel de factores de la transcripción y la replicación del ADN en el origen de la inestabilidad genómica.
… relevancia, los bucles R (más conocidos como R-loops). De origen primordialmente co-transcripcional, los R-loops están constituidos por una cadena sencilla de ADN desplazada y un híbrido de ARN:ADN formado entre el ARN y su hebra de ADN molde. Los híbridos de ARN:ADN son estructuras naturales, …
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Papel de la helicasa UAP56/DDX39B y otros factores asociados al metabolismo del ARN en la integridad del genoma
… generadas se conocen como bucles R (R loops) y están compuestos por un híbrido de ADN-ARN y la cadena sencilla de ADN desplazada. Si bien se ha demostrado que los R loops pueden desempeñar importantes funciones fisiológicas, cuando se forman o acumulan de manera incontrolada pueden …
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DDX47 and MECP2, two novel human functions controlling R-loop-mediated genome integrity
… es la formación de bucles R (en inglés R loops), estructuras formadas por un híbrido de ARN-ADN y la cadena sencilla de ADN desplazada. La formación de estas estructuras tiene lugar durante la transcripción cuando el transcrito de ARN naciente invade hibridando con su hebra molde de ADN, …
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The influence of chromatin in DNA-RNA hybrid metabolism
… uno de los más estudiados es la formación de R loops. Estos son estructuras formadas por un híbrido de ADN-ARN que desplaza la otra hebra del ADN dejándola en forma de cadena sencilla, más susceptible al ataque de determinados agentes como la enzima AID. Aunque los híbridos de ADN-ARN desempeñan …
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RNA-binding Proteins and RNA-DNA Hybrids Regulate Repetitive DNA Stability in Health and Disease
… We find that RNA-DNA hybrid structures and R-loops can form on extra-chromosomal Ty1 cDNA in yeast, but these structures drive Ty1 retromobility through distinct mechanisms. Ty1-associated R-loops drive retromobility through the canonical integration pathway, while Ty1-associated RNA-cDNA …
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Caste-Specific Expression Of Coding And Noncoding Genes In Ant Brains
… phenotype and develop a method to study R-loops, a potential mechanism of lncRNAs. The first section describes how we improved the contiguity of the Harpegnathos genome using PacBio long-read sequencing technology, enabling the annotation of lncRNAs and identification of caste-, brain-, and …
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RNA EXPORT FACTOR ELF1 MAINTAINS GENOME STABILITY IN FISSION YEAST
… formation of DNA-RNA hybrids, known as R-loops, which have been tied to enhanced mutation rates. Supporting this hypothesis, I found that when elf1Δ cells lost RNase H, preventing R-loop degradation, mutation rates increased over 6-fold. As understanding sources of genome instability is …
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DNA Damage Response in Huntington’s Disease and Naked Mole Rat Brain Ageing
… expansion converged on the regulation of R-loops, suggesting that these DNA-RNA hybrid structures may contribute to CAG repeat instability and genomic instability in HD. Integration of these findings highlights the central importance of genomic stability and cellular homeostasis in brain …
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Optimisation of TrAEL-seq to study DNA damage and replication in complex and dynamic mammalian cell systems
… of TrAEL-seq signal around a subset of R-loops in senescent cells, which were localised in subtelomeric regions. Follow-up investigations which characterised the nature and origin of these peak sites offer new perspectives on cellular senescence. Taken together, this work demonstrates …
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The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability
… stability including limiting the formation of R-loops in response to replication stress.
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Post Translational Regulation of AID Targeting to Both Strands of a Transcribed DNA Substrate
… identified DNA secondary structure such as R loops, transcription factors, miRNA, and phosphorylation as events important for determining AID's ability to access its substrate sequences. However, none of these studies demonstrated how AID mutates both strands of DNA, reminiscent to its in vivo …
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A Structural Perspective on Bacterial Transcription
… RNA synthesis but is prone to producing R-loops. We show that RapA helps to control cytotoxic R-loop formation <em>invivo</em>, likely by disrupting PTCs. Nucleotide binding to RapA triggers a conformational change that opens the RNAP clamp, allowing DNA in the RNAP cleft to reanneal and …