Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Quinpirole"”.
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Chronic Olanzapine Treatment Eliminates Cognitive Deficits Produced by Neonatal Quinpirole Treatment.
… Animals were neonatally treated with quinpirole, a dopamine D<sub>2</sub> receptor agonist, or saline. Quinpirole treatment produces an increase of dopamine D<sub>2</sub> receptor sensitivity that extends into adulthood, known as D<sub>2</sub> receptor priming, similar to a phenomenon …
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The effects of quinpirole in eliciting 50 kHz calls from the rat nucleus accumbens /
… in adult rats. Single injections of quinpirole in a saline vehicle were administered to the nucleus accumbens shell of 57 rats, and the number of 50 kHz vocalizations were recorded. An inverted V-shaped relationship was found between quinpirole dose (0.5 ~g, 3 ~g, 6 ~g, 1 0 ~g and 20 …
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The Effects of Nicotine Administration on Behavior and Markers of Brain Plasticity in a Rodent Model of Psychosis
… Methods: Rats were neonatally treated with quinpirole (a D2/D3 agonist) or saline and sensitized to 0.3, 0.5, or 0.7 mg/kg (free base) nicotine or saline, every other day for 9 days, and locomotor activity was recorded. After behavioral testing, animals demonstrating sensitization to …
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The effects of a mixed dopamine D2/D3 agonist and antagonist on ethanol intake within a limited and a continuous access paradigm
The effects of the mixed dopamine D2/D3 agonist, quinpirole and antagonist, raclopride on ethanol consumption were examined within both a limited and a continuous access paradigm. The goals of these studies were to determine if decreases in ethanol intake after administration of the dopaminergic …
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Dopamine D2 Receptor Priming Enhances Dopaminergic Response to Amphetamine in the Nucleus Accumbens: Role of the D1 and D2 Receptors.
<p>In past work, we have shown neonatal quinpirole (dopamine D<sub>2</sub>/D<sub>3</sub> agonist) treatment produces a significant increase in dopamine D<sub>2</sub> receptor sensitivity, a phenomenon known as D<sub>2</sub> receptor priming. Dopamine D<sub>2</sub> receptor priming is common in …
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Amphetamine Sensitization and <em>in vivo</em> Microdialysis of the Nucleus Accumbens Core of Adult Male and Female Rats D2-Primed as Neonates.
<p>Neonatal administration of quinpirole produces significant increases in D<sub>2</sub> receptor sensitivity that persists into adulthood. This phenomenon, known as D<sub>2</sub> receptor priming, is consistent with pathology in schizophrenia. Rats were administered quinpirole or saline …
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Study of the Role of the Bed Nucleus of the Stria Termialis D1- and D2-Like Dopamine Receptors in Cocaine Self-Administering Rats
… dose), and D2- dopamine receptor agonist Quinpirole (3.0 microgram total bilateral dose), administered into the BST immediately prior to self-administration sessions, were examined in both sucrose (180-minute sessions) and cocaine (270-minute sessions) self-administering rats. Injections …
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Gut-brain axis: Central impact of gut peptides and metabolic drug on monoamine neurotransmission
… agent) -induced motor activity, quinpirole (a dopamine D2/D3 receptor agonist) and pramipexole (a dopamine D3 preferred receptor agonist) -induced yawning, pica eating and pelvic grooming activities, as well as phencyclidine ( an N-Methyl-D-aspartate receptor antagonist)-induced …
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RGS2 Modulation of Dopamine D2 Receptor Trafficking in Neuroblastoma Cells
… role of RGS2 knockdown in the modulation of quinpirole, a D2/D3 agonist, stimulated D2R internalization, recycling and β-arrestin translocation and distribution. This study provides evidence that RGS2 plays a vital role in modulation of D2R trafficking and could potentially serve as a target …
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Anatomical and Physiological Characterization of Striatal Activation of the Cerebral Cortex
… of L-dopa/ D1 agonist SKF81297/ D2 agonist quinpirole/ saline into the right striatum/right motor cortex was performed 75 min before mouse perfusion. Second, c-Fos mapping was used to evaluate neuronal activity. C-Fos is an immediate-early gene with activity-dependent protein expression that …
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Effect of dopamine on synchronous neuronal oscillations in the globus pallidus-subthalamic nucleus network
… (10 μM) and the D2-like receptor agonist quinpirole (10 μM). However, the excitation was partially reduced by the D1-like antagonist SCH23390 (2 μM) but not by the D2-like antagonists sulpiride (10 μM) and eticlopride (10 μM). Using whole-recordings, dopamine was shown to induce membrane …
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Neuromodulation and neural circuits underlying cognitive flexibility in the rat
… on D2 receptors. We found that the D2 agonist quinpirole impaired reversal learning when given systemically, an effect that depended on decreased sensitivity to negative feedback, but improved performance when given directly into the nucleus accumbens. In chapter 5, the synaptic location of D2 …
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Novel Modulation of Adenylyl Cyclase Type 2
… modestly enhanced the potency of acute quinpirole-induced D<sub> 2L</sub>DR modulation of AC1 or AC2 activity. AGS3 also promoted desensitization of D<sub>2L</sub> DR-mediated inhibition ofAC1, whereas desensitization of D2LDR-mediated AC2 activation was significantly attenuated. …
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Characterization of Rimonabant effects on G protein activity
… to evaluate the effects of SR on baclofen and quinpirole-induced outward K+ current both in wild-type (WT) and CB1-KO mice. In addition, in order to demonstrate that SR induced the inhibition of GIRK channel activity by acting directly on G protein, we use a GPCR-free experimental setup (i.e. …
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The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
… to cocaine seeking triggered by the D2 agonist quinpirole, when compared to low intake rats. Additionally, high intake rats developed profound increases in locomotor responses to D2 receptor challenge from early to late withdrawal times, whereas low intake rats developed increased responsiveness …