Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Quinone reductase (QR)"”.
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Breast Cancer Inhibition by Grape Constituents
… such as glutathione S-transferase (GST) and quinone reductase (QR). These grape components also suppressed reactive oxygen species (ROS) formation. The constituents did not induce antioxidant response element (ARE)-dependent transcription. These data indicate that grape polyphenols have …
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Cancer Chemoprevention by Curcumin and Structurally Related Beta-Diketones
… various compounds for their capacity to induce quinone-reductase (QR) activity in wild-type Hepa1c1c7 cells and a mutant subdone, curcumin and dibenzoylmethane were found to be most effective. However, when added to semipurified diets fed to female rats, dibenzoylmethane (1%), but not curcumin …
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Hormetic dietary phytochemicals from Western Canadian plants: Identification, characterization and mechanistic insights
… that activate the stress-responsive enzyme quinone reductase (QR) by stabilizing the transcription factor NF-E2 related factor-2 (Nrf2). Screening methanolic extracts of plants from Western Canada for QR induction in a mouse hepatoma cell line (Hepa-1c1c7) led to the identification of …
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The effect of a dietary phase 2 protein inducer on inflammatory parameters in blood and liver of spontaneously hypertensive stroke prone rats
… induction results in higher activities of liver quinone reductase (QR), glutathione-S-transferase (GST) and glutathione reductase (GR)). My experimental results demonstrated that broccoli sprout feeding results in higher protein thiol levels in female SHRsp and higher blood GSH levels in males …
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Determination of Relative Cancer Preventative Effects of Cruciferous Vegetables
… ability to induce detoxification enzymes such as quinone reductase (QR). Our aim was to identify a means to compare potency among crucifer varieties. We fed Fisher 344 rats button or whole Brussels sprouts (BS) and found that both diets induced QR activity to the same extent. This finding has …
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Improving the Health Benefit of Broccoli by Maximizing Sulforaphane Formation: A Role for Epithiospecifier Protein
… inducer of the phase II detoxification enzymes quinone reductase (QR) and glutathione S-transferase (GST). Mild heat treatment was found to dramatically increase the formation of sulforaphane from broccoli while decreasing the formation of the alternative nitrite product. A heat sensitive …
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Enhancing human health promoting activity through the regulation of the methyl jasmonate mediated glucosinolate biosynthesis in Brassica oleracea
… if MeJA treatment can enhance induction of quinone reductase activity, an anticancer biomarker of broccoli floret extracts, MeJA treatments were applied to five broccoli cultivars in each of two years under field conditions (Chapter 3). Sulforaphane, phenethyl isothiocyanate, and hydrolysis …
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The glucosinolate/myrosinase system: variation in glucosinolates, hydrolysis products, transcript abundance, and quinone reductase bioactivity in Brassica sp. crops
Glucosinolates, and more specifically their hydrolysis products, are secondary metabolites present in Brassica crops that are important for plant defense from insects and pathogens. In addition, these compounds have long been associated with anti-cancer activity in mammals through the induction of …