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Showing 1 to 17 of 17 for “"Quinone reductase"”.
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Bicarbonate Reversible Anionic Inhibition of the Quinone Reductase in Photosystem II
… The oxidation of Q$\sb{\rm A}\sp-$ (the primary quinone acceptor of PS II) by Q$\sb{\rm B}$ or Q$\sb{\rm B}\sp-$ (Q$\sb{\rm B}$ is the secondary quinone acceptor of PS II) exhibited a smaller overall half-time at pH 7.5 than at pH 6.5 in HCO$\sb3\sp-$-depleted or treated membranes. However, the …
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The glucosinolate/myrosinase system: variation in glucosinolates, hydrolysis products, transcript abundance, and quinone reductase bioactivity in Brassica sp. crops
Glucosinolates, and more specifically their hydrolysis products, are secondary metabolites present in Brassica crops that are important for plant defense from insects and pathogens. In addition, these compounds have long been associated with anti-cancer activity in mammals through the induction of …
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Iron and reactive oxygen in wheat-pathogen interactions
… own oxidative defences, I characterise a novel quinone redox cycle, and show that simultaneous induction of a protective quinone reductase isoform and downregulation of reactive oxygen-producing quinone reductase isoform prevents the spread of reactive oxygen during pathogen attack. Finally, in …
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Design, Synthesis, And Evaluation Of Molecular Inhibitors For Biologically Relevant Enzymes
… polyphenol resveratrol and its inhibition of the quinone reductase 2 (QR2) enzyme. The work on this subject resulted in the complete design, synthesis, biological and structural evaluation of a second generation library of resveratrol analogues. From this work we identified a novel resveratrol …
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Evaluation of the induction of rat hepatic and pancreatic glutathione S-transferases by treatment with the cruciferous nitrile, cyanohydroxybutene
… CHB also induces hepatic and pancreatic GST and quinone reductase activities and hepatic GSH reductase activity.
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Assessing Hepatic Gene Expression in Response to Xenobiotic Exposure in Mice
… II gene transcription factor (P = 0.03) and quinone reductase 02 (P = 0.007) on d 5, and Gstm1 on d 8 (P = 0.04) and d 11 (P = 0.01). Moreover, sulforaphane treated mice had higher (P < 0.05) Gstm1 expression across days. Among enzymes, only sufloraphane treated mice had higher (P < 0.05) Gst …
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Breast Cancer Inhibition by Grape Constituents
… such as glutathione S-transferase (GST) and quinone reductase (QR). These grape components also suppressed reactive oxygen species (ROS) formation. The constituents did not induce antioxidant response element (ARE)-dependent transcription. These data indicate that grape polyphenols have …
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Cancer Chemoprevention by Curcumin and Structurally Related Beta-Diketones
… various compounds for their capacity to induce quinone-reductase (QR) activity in wild-type Hepa1c1c7 cells and a mutant subdone, curcumin and dibenzoylmethane were found to be most effective. However, when added to semipurified diets fed to female rats, dibenzoylmethane (1%), but not curcumin …
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Hormetic dietary phytochemicals from Western Canadian plants: Identification, characterization and mechanistic insights
… that activate the stress-responsive enzyme quinone reductase (QR) by stabilizing the transcription factor NF-E2 related factor-2 (Nrf2). Screening methanolic extracts of plants from Western Canada for QR induction in a mouse hepatoma cell line (Hepa-1c1c7) led to the identification of …
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The effect of a dietary phase 2 protein inducer on inflammatory parameters in blood and liver of spontaneously hypertensive stroke prone rats
… induction results in higher activities of liver quinone reductase (QR), glutathione-S-transferase (GST) and glutathione reductase (GR)). My experimental results demonstrated that broccoli sprout feeding results in higher protein thiol levels in female SHRsp and higher blood GSH levels in males …
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Determination of Relative Cancer Preventative Effects of Cruciferous Vegetables
… ability to induce detoxification enzymes such as quinone reductase (QR). Our aim was to identify a means to compare potency among crucifer varieties. We fed Fisher 344 rats button or whole Brussels sprouts (BS) and found that both diets induced QR activity to the same extent. This finding has …
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Improving the Health Benefit of Broccoli by Maximizing Sulforaphane Formation: A Role for Epithiospecifier Protein
… inducer of the phase II detoxification enzymes quinone reductase (QR) and glutathione S-transferase (GST). Mild heat treatment was found to dramatically increase the formation of sulforaphane from broccoli while decreasing the formation of the alternative nitrite product. A heat sensitive …
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Characterisation of cytochrome c MtoD from the iron-oxidising autotroph sideroxydans lithotrophicus ES-1
… from MtoA to the predicted inner membrane quinone reductase CymAES-1 (Shi et al. 2012). Very little is understood about the electron transfer pathways in S. lithotrophicus and the current model (Shi et al. 2012) does not propose a mechanism that would allow NADH and ATP to be generated for …
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Enhancing human health promoting activity through the regulation of the methyl jasmonate mediated glucosinolate biosynthesis in Brassica oleracea
… if MeJA treatment can enhance induction of quinone reductase activity, an anticancer biomarker of broccoli floret extracts, MeJA treatments were applied to five broccoli cultivars in each of two years under field conditions (Chapter 3). Sulforaphane, phenethyl isothiocyanate, and hydrolysis …
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Enrichment of tomatoes and broccoli with specific bioactives for the reduction of prostate carcinogenesis
… All broccoli diets increased activity of colon quinone reductase (NQO1). Indole glucosinolate-enriched broccoli and selenium-enriched broccoli increased hepatic NQO1 and cytochrome P450 1A activity (P < 0.05). Different tomato diets resulted in altered hepatic accumulation of lycopene, …
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Flavonoid protection of cardiac cells against ischemia-reperfusion injury
… activity of glutamate cysteine ligase (78%) and quinone reductase (147%) in hearts. The sprouts group was the only group which induced these same enzymes in liver (40 and 44 %, respectively), as it was the only intervention which elevated total liver glutathione (12%). None of the interventions …
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Biochemical characterization of respiratory chain flavoproteins
… from Streptococcus agalactiae • The sulfide:quinone oxidoreductase (SQR) from the archaeon Caldivirga maquilingensis • The NDH-2 from Thermus thermophilus, now re-classified as a coenzyme A disulfide reductase (CoADR) NDH-2 catalyzes the same reaction (NADH:quinone oxidoreductase) as complex …