Global ETD Search
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Showing 1 to 2 of 2 for “"Quinone biosynthesis"”.
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Targeting isoprenoid and quinone biosynthesis for antimicrobial discovery
"Enzymes in isoprenoid biosynthesis pathway play important roles in all living organisms. Here we report the first structure of heptaprenyl diphosphate synthase from Staphylococcus aureus (SaHepPPS) together with an investigation of its mechanism of action, and inhibition. HepPPS is involved in …
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Mechanisms of bacterial polyprenyl transferases and multi-target drug discovery for tuberculosis
… that are involved in bacterial cell wall biosynthesis, biofilm formation, virulence formation and natural product formation. Structurally, bacterial polyprenyl transferases can be categorized into eight groups: αcyclase, α, αβ, αβγ, βγ, ε, ζ and TIM barrel fold proteins. Six bacterial …