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Showing 1 to 20 of 217 for “"Quinone"”.
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Novel quinone syntheses
… of the syntheses of a number of novel quinones. Chapter I deals with the syntheses of quinonoid derivatives of the compounds isobenzofuran and isoindole. These are the parent species of that series of heterocyclic compounds which contain a single heteroatom and are isoelectronic with …
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REVERSIBLE QUINONE METHIDE ALKYLATION OF DNA
… cause cancer and also to serve as its treatment. Quinone methides (QMs) are highly electrophilic molecules implicated in numerous metabolism processes. Studies of QM's reversible reaction with nucleophiles of DNA are important to understand the mechanism of its biological activity. Reversible …
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Studies of quinone monooximes derived from dihydroxyphenylalanines
… afforded 6-hydroxy-1,2-naphthoquinone 2-oxime as the main product together with some 6-hydroxy1,4-naphthoquinone 4-oxime as the 4-nitrosated compound, which were separated by using the chelating technique. For the 1,5- and 2,7-dihydroxynaphthalenes only one product resulted, …
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The Conversion of Quinone-Imides to Indoles
Made available in DSpace on 2014-12-05T19:36:13Z (GMT). No. of bitstreams: 1 0013556.pdf: 7327736 bytes, checksum: c4ba3557dc85ce9b981beecc88e9818f (MD5) Previous issue date: 1955
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Targeting isoprenoid and quinone biosynthesis for antimicrobial discovery
… and inhibition. HepPPS is involved in menaquinone biosynthesis, a key electron transporter in many pathogens. It is a heterodimer consisting of a catalytic subunit and a regulatory subunit. High concentrations of substrates (FPP and IPP) inhibit the enzyme, which is also inhibited by …
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Studies of 1,2-quinone monooximes and their metal complexes
The chemistry of 1,2-quinone monooximes hi« been reviewed. The synthesis of 5-amlno, 5-alkylamino and 5-acylamino substituted 1,2-benzoquinone monooximes was systematically studied. Thus, It has been found that 5-amino-1,2-benzoquinone-2-oxime (5-AqoH), 5-ethylamino-4-methyl 1-1,2- …
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Studies Towards The Novel Synthesis Of Benzoisochromane Quinone Polyketides
… unique member of the benzoisochromane quinone (BIQ) family of antibiotics. The molecule and its derivative exhibit a sugar moiety fusted to the naphthazarin core, only exhibited by one other natural compound, by a C-C glycosidic bond and an aldol like bond. The mechanism of enzymatic …
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Studies of 1,2-quinone mono-oximato complexes and their redox reactions
The synthesis of the complexes Cr(1-nqo)3, Cr(2-nqo)3, Cr(3-Me-5-OHqo)3, Cr(6-Me-5-OHqo)3, Mn(1-nqo)3, Mn(2-nqo)3, Mn(1-nqo)2, and Mn(2-nqo)2, has been systematically examined.
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Quinone-Catalyzed Amine α-C–H and α-C–C Functionalization
… by enzymatic catalysis, we studied sequential quinone-catalyzed oxidation/nucleophilic addition reactions of primary aromatic amines to quickly access corresponding α-substituted amines. The developed reaction conditions can be effectively applied to gram-scale synthesis. The excellent …
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Biomimetic synthesis of natural products via reactions of ortho-quinone methides
… This thesis will describe the use ortho-quinone methides and cascade reactions towards the biomimetic synthesis of the penilactones A and B, the peniphenones A-D, virgatolide B and epicolactone. The total synthesis of ent-penilactone A and penilactone B has been achieved via biomimetic …
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Bicarbonate Reversible Anionic Inhibition of the Quinone Reductase in Photosystem II
… The oxidation of Q$\sb{\rm A}\sp-$ (the primary quinone acceptor of PS II) by Q$\sb{\rm B}$ or Q$\sb{\rm B}\sp-$ (Q$\sb{\rm B}$ is the secondary quinone acceptor of PS II) exhibited a smaller overall half-time at pH 7.5 than at pH 6.5 in HCO$\sb3\sp-$-depleted or treated membranes. However, the …
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Optimization of Quinone-Based, Extracellular Electron Transfer Mediators for Bioelectronic Applications
… or electron shutting compounds (ESCs). Quinones, a class of cyclic, conjugated, di-keto compounds often serve as ESCs. Lactiplantibacillus plantarum, a commensal lactic acid bacterium, can utilize quinoline-mediated EET through a type II NADH dehydrogenase protein, Ndh2. In nature, …
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Metal complexes of 1,2-quinone monooximes and their applications in organic synthesis
Systematic investigations of the reactions of 1,2-quinone monooximes (qoH) with alkali (lithium, sodium and potassium) and alkaline earth metal (magnesium and barium) hydroxides and acetates [M(OH)n or M(OAc)r] have been carried out.
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Studies on the Photoreduction of Quinone Analogues in Bacterial Photosynthetic Reaction Centers
Made available in DSpace on 2014-12-15T23:19:00Z (GMT). No. of bitstreams: 1 8721709.pdf: 7766249 bytes, checksum: 5eee5ad815c5641146d939f706d0fe43 (MD5) Previous issue date: 1986
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Electronic and Molecular Structures of Metal-Quinone and Iron Porphyrin Perchlorate Complexes
Made available in DSpace on 2014-12-13T20:10:48Z (GMT). No. of bitstreams: 1 8009072.pdf: 5725892 bytes, checksum: aba346defda74d88b84157393db1bd81 (MD5) Previous issue date: 1979
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The anticancer mode of action of the quinone natural product cribrostatin 6
Cribrostatin 6 is a quinone-containing natural product that induces the death of cancer cell lines in culture, but its mechanism of action and scope of activity are unknown. Quinone based drugs have shown potential in the clinic, making cribrostatin 6 an interesting compound to study. The mode of …
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Synthesis of naphtho{2,3-c}pyrans including the aphin-derived quinone A'
… the synthesis of a trifluoroethylnaphtho-1, 4-quinone via a regiospecific trifluoroacetylation of an appropriately substituted naphthalene. Chapter Two describes the synthesis of the methyl ethers of the naturally occurring quinones A and deoxyquinone A for evaluation of their "anti-cancer" …
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Studies of 1,2-quinone mono-oximato complexes and of their oxidation of amines
… amine adducts of Cu(qo), where qoH = 1,2-naphthoquinone 1-oxime (1-nqoH), 1,2 naphthoquinone 2-oxime (2-nqoH), 4-chloro-1, 2-benzoquinone 2-oxime (4-ClqoH), 4-methyl-1, 2-benzoquinone 2-oxime (4-MeqoH) have been examined.
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Developing and Investigating the Scope of Quinone-Functionalised Carbons for Electrochemical Carbon Dioxide Capture
… consumption. Redox-active molecules such as quinone-based molecules have been utilised in this area but suffer from low cycling stability due to organic molecules leaking into the electrolyte. Anthraquinone is a common organic molecule for this process because it is highly stable under …
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