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Showing 1 to 5 of 5 for “"Quinazolinones"”.
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Synthesis, characterisation, structure-activity and structure-property relationship studies of quinazolinones as antimycobacterial agents
… especially the emergence of resistance. Quinazolinones have shown a range of biological activities including anti-cancer, enzyme inhibition, receptor antagonists and agonists, antiplasmodial, antibacterial and anti-tubercular activity. Within the context of work undertaken in this MSc …
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Synthesis of 3-Aryl-2-(2-aryl-2-oxoethyl)pyrido[2,3-d]-4(3H)pyrimidones and 3-Aryl-2-(2-arylethenyl)pyrido[2,3-d]-4(3H)pyrimidones as Potential Antiepileptic Drugs
… displayed by a series of 2-alkyl-3-aryl-4(3H)-quinazolinones prepared previously in our research group. From the pharmacological testing data of these target compounds, we have found that the additional nitrogen at the C-8 position of the quinazolinone framework increased the anticonvulsant …
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Part A, Synthesis of new 2-substituted-3-aryl-4(3H)-quinazolinones as potential CNS agents: part B, Reactions of β-diketones with benzophenone in the presence of potassium hydride
… and various other 2-methyl-3-aryl-4(3H)-quinazolinones were functionalized by active hydrogen condensations at the 2-methyl position. For example, methaqualone was metalated at the lateral 2-methyl group with lithium diisopropylamide at O⁰ in tetrahydrofuran (THF) and the resulting lithio …
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The synthesis and reactions of sulphur analogues of deoxyvasicinone
… of the thiazolo -, thiazin - and thiazepino- quinazolinones (A)-(C) was achieved, by the condensation of anthranilic acid with appropriate sulphur containing lactams, in the presence of phosphoryl chloride. The quinazolinones (A) and (B) were shown to react (at the methylene group alpha to the …
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Elucidating the Target and Selectivity of a Non-Small Cell Lung Cancer Toxin
Selective toxicity among cancer cells of the same lineage is a hallmark of targeted therapies, and so identifying compounds that impair proliferation selectively is an important strategy in drug development. Here, we report the discovery of the quinazoline dione compound (QDC), a molecule that …