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Showing 1 to 5 of 5 for “"Queuosine"”.
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The Cellular and Molecular Dynamics of the Queuosine Modification in Transfer RNA: Definition, Modulation, Deficiencies and Effect of the Queuosine Modification System
<p>The presence of the queuosine modification in the wobble position of tRNA<sup>asn</sup>, tRN<sup>asp</sup>, tRNA<sup>his</sup>, and tRNA<sup>tyr</sup> is associated with a decrease in cellular growth rate, an increase in the ability to withstand environmental stress, and differentiation of …
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Elucidation of the Biosynthetic Pathway for 7-Deazapurines
… and antineoplastic activity. In addition, queuosine, a hypermodified nucleoside located in the wobble position of select tRNAs that is almost universally conserved throughout biology, contains a 7-deazapurine functional group. The since their initial identification over 50 years ago, the …
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Structural studies of S-adenosyl-L-methionine radical enzymes involved in tRNA and natural product biosynthesis
… of the tRNA modified bases wybutosine and queuosine. TYWI catalyzes the formation of the characteristic imidazopurine ring of wybutosine through a disputed mechanism. Here, we have garnered support for one of the proposed mechanisms, through the identification and characterization of a …
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Development of pattern recognition technique for classification of RNA secondary structures by small molecules
… Response element, fluoride riboswitch and pre-queuosine 1 riboswitch could be differentiated based on the position of the fluorophore using the training set clusters. This method provides insight into both the RNA topological and conformational elements and the small molecule ligand properties …
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The Role of Base Modifications on Tyrosyl-tRNA Structure, Stability, and Function in Bacillus subtilis and Bacillus anthracis
tRNA molecules contain more than 80 chemically unique nucleotide base modifications that contribute to the chemical and physical diversity of RNAs as well as add to the overall fitness of the cell. For instance, base modifications have been shown to play a critical role in tRNA molecules by …