Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Quantitative systems pharmacology"”.
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Biochemical Thermodynamic Modelling of Cellular Bioenergetics: A Quantitative Systems Pharmacology Approach
In this thesis, thermodynamic-based mathematical modelling is combined with experimental in vitro extracellular flux analysis in order to assess drug redox cycling and cellular bioenergetics. It is widely accepted that pharmacological activity of certain classes of drugs (e.g. anticancer, …
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Approximation of Large Stiff Acausal Models
… productivity whilst designing practical systems. In particular, simulating systems with widely separated timescales are prone to computational problem called stiffness. In this thesis, we aim to alleviate these issues by the use of approximate models called surrogates, which match the …
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Mechanistic modeling of alpha-synuclein aggregation and brain pharmacokinetics for drug development in neurodegeneration
… on foundational and methodological aspects of quantitative systems pharmacology (QSP) and physiologically based pharmacokinetic (PBPK) modeling. The first part of the work focuses on the mathematical modeling of alpha-synuclein (aSyn) aggregation dynamics under in vitro conditions—a molecular …
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Towards systems pharmacology models of druggable targets and disease mechanisms
… for the full complexity of biology in humans. Systems pharmacology models are a likely candidate for increasing the efficiency of drug discovery as they seek to comprehensively model the fundamental biology of disease mechanisms in a quantit- ative manner. They are computational models, …