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Showing 1 to 8 of 8 for “"Quantitative Fluorescence Microscopy"”.
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Protein segregation and conformation in antigen-receptor triggering: a quantitative fluorescence microscopy study
… triggering. Total internal reflection fluorescence microscopy is used to establish that phosphatase exclusion decreases when intermembrane distance increases. This inverse relationship, demonstrated for both B cells and T cells, is consistent with the kinetic-segregation model. However, …
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Vascular Permeability of the MDA-MD-231BR and RG-2 Brain Tumor Using Quantitative Fluorescence Microscopy
Embargo status: Restricted to TTU community only. To view, login with your eRaider (top right). Others may request the author grant access exception by clicking on the PDF link to the left.
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Heterogeneity in the population response of a human cell line to hydrogen peroxide as measured by a genetically encoded sensor
… sensor, HyPer, expressed in HeLa cells. Using quantitative fluorescence microscopy, we found significant heterogeneity in HyPer response among the cell population. Further analysis showed that the variation in HyPer response was dependent on expression of HyPer protein as well as on cell cycle …
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Advancing Dynamic Imaging for Microfluidic Stimulated Tissues: Biology, Techniques, and Applications
Using quantitative fluorescence microscopy imaging of cellular activities in intact tissues stimulated in a microfluidic device creates opportunities for studying major diseases such as diabetes and cancer. Despite a number of documented phenotypic traits of these diseases, the underlying …
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Molecular titration by MicroRNAs and target mimic inhibitors
… assay repression in single cells, we performed quantitative fluorescence microscopy and flow cytometry to monitor a target gene's protein expression in the presence and absence of regulation by miRNA. We found that repression among individual cells varies dramatically. miRNAs establish a …
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Bioimage informatics for understanding the effects of chemotherapy on cellular signaling, structure, and function
… remain poorly understood. Consequently, quantitative characterization of molecular signaling pathways and changes in cancer cell phenotypes induced by chemotherapy through the use of in vitro model systems would expand our understanding of drug mechanisms and provide for putative …
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Synthetic In Vivo Reconstitution of Asymmetric Cell Division
… into large, two-dimensional lattices. Using quantitative fluorescence microscopy and Atomic Force Microscopy, we demonstrated that these lattices assemble in a near-crystalline fashion on cells. With these proteins, robust asymmetric ‘caps’ of plasma membrane complexes could be generated. …
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Dynamics of Cell Fate Decisions Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observations
… our dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells we have provided a systems biology experimental framework to study dynamical aspects of autophagy …